81409-74-7 Usage
Description
6-(2-PROPENYL)-ERGOLINE-8-CARBOXYLIC ACID, also known as 6-Allyl-8β-carboxyergoline, is a metabolite of cabergoline, a dopamine D2-receptor agonist. It is derived from the ergoline alkaloid family and plays a significant role in the treatment of various medical conditions.
Uses
Used in Pharmaceutical Industry:
6-(2-PROPENYL)-ERGOLINE-8-CARBOXYLIC ACID is used as an active pharmaceutical ingredient for the development of medications targeting dopamine D2-receptor agonism. Its application is primarily for the treatment of conditions such as Parkinson's disease, hyperprolactinemia, and certain pituitary tumors, where modulation of dopamine receptors can provide therapeutic benefits.
Used in Research Applications:
In the field of scientific research, 6-(2-PROPENYL)-ERGOLINE-8-CARBOXYLIC ACID serves as a valuable compound for studying the mechanisms of dopamine receptor interactions and their implications in neurological and endocrine disorders. This research can contribute to the development of novel therapeutic strategies and a better understanding of the underlying biology of related diseases.
Used in Drug Metabolism Studies:
6-(2-PROPENYL)-ERGOLINE-8-CARBOXYLIC ACID is utilized in drug metabolism studies to understand the biotransformation pathways of cabergoline and related compounds. This knowledge is crucial for assessing the safety, efficacy, and pharmacokinetics of these medications, ensuring optimal dosing regimens and minimizing potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 81409-74-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,4,0 and 9 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 81409-74:
(7*8)+(6*1)+(5*4)+(4*0)+(3*9)+(2*7)+(1*4)=127
127 % 10 = 7
So 81409-74-7 is a valid CAS Registry Number.
InChI:InChI=1/C18H20N2O2/c1-2-6-20-10-12(18(21)22)7-14-13-4-3-5-15-17(13)11(9-19-15)8-16(14)20/h2-5,9,12,14,16,19H,1,6-8,10H2,(H,21,22)/t12-,14-,16-/m1/s1
81409-74-7Relevant articles and documents
Synthesis of European pharmacopoeial impurities A, B, C, and D of cabergoline
Wagger, Jernej,Pozes, Aljaz,Pozgan, Franc
, p. 23146 - 23156 (2013/11/19)
For the use of analytics, European pharmacopoeial impurities A, B, C, and D of cabergoline were synthesized. Ergocryptine was chosen as a starting material and synthesis was accomplished via two approaches, different in length and stereochemical outcome. A longer, indirect approach was realized through otherwise problematic oxidations of the 9,10-dihidrolysergol derivative, to the corresponding aldehyde and carboxylic acid. This was achieved by the use of activated DMSO and a Pinnick oxidation sequence. All four synthesized impurities are used as analytical standards in cabergoline manufacturing processes.
New and efficient process for the preperation of cabergoline and its intermediates
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Page/Page column 12-13, (2008/12/08)
This invention relates to a new and efficient process for the production of dopamine agonists such as Cabergoline and the intermediates thereof.
