25528-71-6

Basic information

• Product Name: H-CHA-OH HCL
• Synonyms: H-PHE(HEXAHYDRO)-OH HCL;L-CYCLOHEXYLALANINE HYDROCHLORIDE;L-2-AMINO-3-HEXAHYDROPHENYL-PROPIONIC ACID HYDROCHLORIDE;L-2-AMINO-3-CYCLOHEXYL-PROPIONIC ACID HYDROCHLORIDE;L-3-CYCLOHEXYLALANINE HYDROCHLORIDE SALT;HEXAHYDRO-L-PHENYLALANINE HCL;HEXAHYDRO-L-PHENYLALANINE HYDROCHLORIDE;H-CHA-OH HCL
• CAS NO: 25528-71-6
• Molecular Formula: C₉H₁₇NO₂*ClH
• Molecular Weight: 207.7
• Mol File: 25528-71-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 232-237℃ (DEC.)
• Appearance: /
• Storage Temp.: Store at RT.
• CAS DataBase Reference: H-CHA-OH HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-CHA-OH HCL(25528-71-6)
• EPA Substance Registry System: H-CHA-OH HCL(25528-71-6)

Safety Data

• Hazardous Substances Data: 25528-71-6(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

Upstream product

• 40056-18-6 methyl L-cyclohexylalaninate 
• 63-91-2 L-phenylalanine 
• 17193-39-4 methyl 3-cyclohexyl-L-alaninate hydrochloride 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 110449-44-0 <(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> <(2S)-2-(N,N'-di-tert-butoxycarbonyl)>hydrazino-3-phenylpropionate 
• 110508-12-8 <(1S,2R)-10-(dicyclohexylaminosulfonyl)born-2-yl> 3-phenylpropionate 
• 407578-45-4 (3S,6S)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione 
• 219916-56-0 (3S,6S)-N,N'-bis(4-methoxybenzyl)-3-isopropyl-6-(cyclohexylmethyl)piperazine-2,5-dione 
• 100400-96-2 (S)-2-acetylamino-3-cyclohexylpropionic acid 
• 110449-53-1 <(1S,2R)-10-(N,N-dicyclohexylaminosulfonyl)born-2-yl> (2S)-2-amino-3-cyclohexylpropionate 
• 2018-61-3 (S)-2-acetylamino-3-phenylpropanoic acid 

Downstream Products

• 37736-82-6 (S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid 
• 17193-39-4 methyl 3-cyclohexyl-L-alaninate hydrochloride 
• 1469996-72-2 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(4-bromophenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide 
• 1469996-70-0 2-(benzyloxy)-5-chloro-N-[(2S)-1-[(3-trifluoromethylphenyl)amino]-1-oxo-3-cyclohexylpropan-2-yl]benzamide 
• 1469996-65-3 (2S)-2-[[2-(benzyloxy)-5-chlorobenzoyl]amino]-3-cyclohexylpropanoic acid 
• 1469996-58-4 methyl (2S)-2-[[2-(benzyloxy)(5-chlorobenzoyl)amino]-3-cyclohexyl]propanoate 
• 1227477-20-4 C₂₂H₂₄BrClN₂O₃ 
• 1227477-18-0 C₂₃H₂₄ClF₃N₂O₃ 
• 1238432-39-7 (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid 
• 639520-15-3 (2S)-3-cyclohexyl-2-(1,1-dioxo-benzo[d]isothiazol-3-ylamino)-propionic acid 

Relevant articles and documents

DIAMINOPROPANOL RENIN INHIBITORS

Described are diaminopropanols of which are orally active and bind to renin to inhibit its activity. They are useful in the treatment or amelioration of diseases associated with elevated levels of renin activity or in the treatment of aspartic protease me

Conjugate additions of organocuprates to a 3-methylene-6-isopropyldiketopiperazine acceptor for the asymmetric synthesis of homochiral α-amino acids

Addition of a range of organocuprates to (S)-N,N′-bis(p-methoxybenzyl)-3-methylene-6-isopropylpiperazine-2, 5-dione 8 affords cis-3-isopropyl-6-alkyldiketopiperazines in excellent yield and >95% de. Subsequent deprotection and hydrolysis of these cis-3-isopropyl-6-alkyldiketopiperazines affords homochiral (S)-α-amino acids in excellent yield.

Poststatin, a new inhibitor of prolyl endopeptidase. VII. N-cycloalkylamide analogues

Poststatin analogues containing (S)-2-oxo-2-(2-pyrrolidinyl)acetyl moiety in P1 were synthesized and examined for their inhibitory activity against prolyl endopeptidase and cathepsin B in vitro. Introduction of non-peptidyl cycloalkylamine component in P'1 was effective and P3-acyl groups must be widely modifiable for prolyl endopeptidase inhibition. Acyl-L-phenylalanyl-(S)-2-oxo-2-(2-pyrrolidinyl)acetyl-cycloalkylamide type compounds showed IC50 value of nano to subnano g/ml as prolyl endopeptidase inhibitor and were shown no significant inhibitory activities against cathepsin B, a cysteine protease.