25572-88-7

Basic information

• Product Name: 5-amino-5-deoxy-1,2-O-isopropylidene-α-D-ribofuranose
• CAS NO: 25572-88-7
• Molecular Weight: 189.211
• Mol File: 25572-88-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-amino-5-deoxy-1,2-O-isopropylidene-α-D-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-5-deoxy-1,2-O-isopropylidene-α-D-ribofuranose(25572-88-7)
• EPA Substance Registry System: 5-amino-5-deoxy-1,2-O-isopropylidene-α-D-ribofuranose(25572-88-7)

Safety Data

• Hazardous Substances Data: 25572-88-7(Hazardous Substances Data)

Upstream product

• 117661-89-9 3-O-benzyl-1,2-O-isopropylidene-5-O-trifluoromethanesulphonyl-α-D-xylofuranose 
• 34370-91-7 3-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranose 
• 532-20-7 α-D-xylofuranose 
• 58-86-6 D-xylose 
• 148703-38-2 5-(benzylamino)-5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose 
• 20881-04-3 1,2:3,5-di-O-isopropylidene-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 75252-13-0 1,2-O-isopropylidene-3,5-di-O-methanesulfonyl-α-D-xylofuranose 
• 131053-15-1 5-azido-3-O-benzyl-5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose 
• 64-17-5 ethanol 
• 109819-13-8 O¹,O²-isopropylidene-α-D-xylo-pentodiald-1,4-ose-5-phenylhydrazone 
• 4711-03-9 5-azido-5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose 
• 6893-65-8 1,2-di-O-isopropylidene-5-O-tosyl-D-xylofuranose 
• 113455-56-4 5-amino-O¹,O²-isopropylidene-O³-methanesulfonyl-5-deoxy-α-D-xylofuranose 

Downstream Products

• 1097199-97-7 (2R)-2-(2-chlorophenyl)-3-[5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose-5-C-yl]thiazolidin-4-one 
• 1097199-90-0 (2S)-2-(2-chlorophenyl)-3-[5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose-5-C-yl]thiazolidin-4-one 
• 1097199-96-6 (2R)-2-(2,6-dichlorophenyl)-3-[5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose-5-C-yl]thiazoliazolidin-4-one 
• 1097199-89-7 (2S)-2-(2,6-dichlorophenyl)-3-[5-deoxy-1,2-O-isopropylidene-α-D-xylofuranose-5-C-yl]thiazoliazolidin-4-one 
• 1187322-20-8 C₂₄H₃₃N₃O₈ 
• 1361250-01-2 C₂₅H₃₆N₂O₈ 
• 1361250-23-8 C₂₅H₃₆N₂O₇S 
• 1361249-74-2 C₂₁H₃₀N₂O₇ 
• 1361250-21-6 C₂₈H₃₄N₂O₇S 
• 1361250-20-5 C₂₅H₃₆N₂O₇S 
• 1361250-19-2 C₂₂H₃₀N₂O₇S 
• 1361250-18-1 C₂₃H₃₂N₂O₇S 
• 1361250-17-0 C₂₆H₃₈N₂O₇S 
• 1361249-91-3 C₂₉H₃₆N₂O₈ 

Relevant articles and documents

Synthesis and biological evaluation of benzo[f]indole-4,9-diones n-linked to carbohydrate chains as new type of antitumor agents

In this work, we report the synthesis of three series of carbohydrate-based benzo[f]indole-4,9-diones and amino-1,4-naphthoquinone derivatives and evaluated their cytotoxic activity against eight human cancer cell lines. Several compounds showed a promising cytotoxic activity toward the tumor cell lines (half maximal inhibitory concentration (IC50) 10.0 μM). The importance of the substitution pattern of the quinone derivatives on the antitumor activity was also discussed. 3-Carboethoxy-2-methyl-benzo[f]indole-4,9-dione derivatives were more cytotoxic than their parent compounds and amino-1,4-naphthoquinones. Unlike clinically useful anticancer agent doxorubicin, the majority of synthesized compounds did not exhibit any lytic effects against erythrocytes or normal human leukocytes.

Synthesis of a new class of naphthoquinone glycoconjugates and evaluation of their potential as antitumoral agents

A novel series of carbohydrate-based naphthoquinones was synthesized and evaluated for cytotoxicity against different cancer cell lines. The compounds derived from 5-hydroxy-1,4-naphthoquinone (juglone) showed better cytotoxicity profiles against HCT-116, A-549 and MDA-MB 435 human cancer cells than the parent compound. The results suggest that the hydroxyl group on the aromatic ring increased the pro-oxidant activity of these new naphthoquinone derivatives. Furthermore, two derivatives were found to be more active against melanoma cells (MDA-MB435) than the clinically useful anticancer agent doxorubicin, and none of the compounds caused mouse erythrocyte lysis.

NOVEL DERIVATIVES OF ACYL CYANOPYRROLIDINES

A compound of formula (I) or a tautomeric form, regioisomer, stereoisomer, solvate, N-oxide or pharmaceutically acceptable salts thereof; wherein 'a' - is selected from the group consisting of substituted or unsubstituted heterocycloalkyl ring and substituted or unsubstituted carbohydrate moiety y is a member selected from -O-, -CO-, -S02-, aminoalkyl or formula (II) wherein, Rw is hydrogen, substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl; x is a member selected from -0-, -S-, -SO-, -S02-, CONR10, NR10CO and -NRd-, or x and y together represent a chemical bond; Z is selected from -CH-, -N-. t is an integer selected from O to 4; with the provisos that when 'a' is substituted or unsubstituted heterocycloalkyl ring then 't' is not O and when y = -CO-, x is not NRd.