25602-68-0

Basic information

• Product Name: Nortropinone hydrochloride
• Synonyms: NORTROPINONE HCL;NORTROPINONE HYDROCHLORIDE;8-Azabicyclo[3.2.1]octan-3-one hydrochloride;(1S,5R)-8-Azabicyclo[3.2.1]octan-3-one hydrochloride;Ntp·HCl;3-Nortropanone Hydrochloride;Desmethyltropinone Hydrochloride;Nortropanone Hydrochloride
• CAS NO: 25602-68-0
• Molecular Formula: C₇H₁₁NO*ClH
• Molecular Weight: 161.63
• EINECS: 1533716-785-6
• Product Categories: pharmacetical;Heterocycle;Various Intermediates;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Building Blocks/Intermediates;Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 25602-68-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: >180°C (dec.)
• Boiling Point: 258.8 °C at 760 mmHg
• Flash Point: 110.3 °C
• Appearance: White to yellow-brown/Solid
• Vapor Pressure: 0.0106mmHg at 25°C
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform, Dichloromethane, Methanol
• Sensitive: Hygroscopic
• CAS DataBase Reference: Nortropinone hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Nortropinone hydrochloride(25602-68-0)
• EPA Substance Registry System: Nortropinone hydrochloride(25602-68-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 25602-68-0(Hazardous Substances Data)

Usage

Description

Nortropinone hydrochloride, a metabolite of Tropinone, is a white to off-white solid with significant applications in the pharmaceutical industry. It serves as an inhibitor for reactions involving the 11 beta-hydroxysteroid dehydrogenase type 1 enzyme, making it a valuable component in drug discovery. Its role as a linker or building block allows for the exploration of a wide range of therapeutics and drugs.

Uses

Used in Drug Discovery:
Nortropinone hydrochloride is used as a building block for the development of various therapeutics and drugs. Its ability to act as an inhibitor in reactions involving the 11 beta-hydroxysteroid dehydrogenase type 1 enzyme makes it a crucial component in the process of drug discovery.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Nortropinone hydrochloride is used as an inhibitor for specific enzymatic reactions. Its chemical properties and inhibitory function contribute to the development of targeted treatments and medications.
Used in Research and Development:
Nortropinone hydrochloride is also utilized in research and development settings, where it serves as a valuable tool for studying the mechanisms of enzymatic reactions and the potential for new drug therapies. Its role as a linker component enables the exploration of various chemical structures and their effects on biological systems.

InChI:InChI=1/C7H11NO.ClH/c9-7-3-5-1-2-6(4-7)8-5;/h5-6,8H,1-4H2;1H

Upstream product

• 50893-53-3 carbonochloridic acid 1-chloro-ethyl ester 
• 532-24-1 tropinone 
• 185099-67-6 Boc-tropinone 
• 799283-74-2 1-chloroethyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate 

Downstream Products

• 130753-13-8 benzyl 3-oxo-8-azabicyclo[3,2,1]octane-8-carboxylate 
• 856900-26-0 3-cyano-8-azabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 
• 900503-08-4 3-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylic acid tert-butyl ester 
• 478837-18-2 3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester 
• 1426257-53-5 8-{2-[(S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetyl}-8-azabicyclo[3.2.1]octan-3-one 
• 1437773-66-4 N-isopropyl-8-(5-phenylthieno[2,3-d]pyrimidin-4-yl)-8-azabicyclo[3.2.1]octan-3-amine 
• 1437774-75-8 8-(5-phenylthieno[2,3-d]pyrimidin-4-yl)-8-azabicyclo[3.2.1]octan-3-one 
• 1437773-60-8 N-cyclobutyl-8-(2-cyclopropyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)-8-azabicyclo[3.2.1]octan-3-amine 
• 1437774-77-0 8-(2-cyclopropyl-5-phenyl-thieno[2,3-d]pyrimidin-4-yl)-8-azabicyclo[3.2.1]octan-3-one 
• 56880-02-5 8-acetyl-8-azabicyclo[3.2.1 ]octan-3-one 
• 1416007-23-2 11-tert-butyl 5-(2-isopropyl-5-methylcyclohexyl) 2-bromo-7,8,9,10-tetrahydro-7,10-epiminocyclohepta[b]indole-5,11(6H)-dicarboxylate 
• 1287375-04-5 (7S,10R)-5-methyl-2-((3-(trifluoromethyl)phenyl)sulfonyl)-5,6,7,8,9,10-hexahydro-7,10-epiminocyclohepta[b]indole 

Relevant articles and documents

RET inhibitor and pharmaceutical composition and application thereof

The invention belongs to the field of medicines, and relates to an RET inhibitor and a pharmaceutical composition and application thereof. Specifically, the invention relates to a compound as shown in a formula (I), or a stereoisomer, a tautomer, a nitrogen oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug of the compound as shown in the formula (I). The invention also relates to pharmaceutical compositions comprising the compounds, and uses of the compounds and pharmaceutical compositions thereof in the preparation of a medicine which is especially used for the treatment and prevention of RET-related diseases and disorders, including cancers, irritable bowel syndrome and/or pain associated with irritable bowel syndrome.

HETEROARYLTHIOMETHYL PYRIDINE DERIVATIVE

The present invention relates to a compound represented by a formula (I): wherein X is a group represented by or the like; Y is a group represented by or the like; and Ar1 is a group represented by or a pharmaceutically acceptable salt thereof.

MODULATORS OF MUSCARINIC RECEPTORS

The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.