130753-13-8

Basic information

• Product Name: N-Cbz-Nortropinone
• Synonyms: N-Cbz-4-Nortropinone;N-Cbz-nortropinone ,97%;8-Cbz-3-oxo-8-azabicyclo[3.2.1]octane;benzyl (1s)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate;8-Azabicyclo[3.2.1]octane-8-carboxylicacid, 3-oxo-, phenylmethyl ester;Benzyl (1S,5R)-3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate;(1R)-tert-Butyl 3-oxo-8-azabicyclo[3.2.1]octane-8-carboxylate;N-CBZ-NORTROPINONE
• CAS NO: 130753-13-8
• Molecular Formula: C₁₅H₁₇NO₃
• Molecular Weight: 259.3
• EINECS: 1533716-785-6
• Product Categories: pharmacetical;Heterocycle
• Mol File: 130753-13-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 415.7 °C at 760 mmHg
• Flash Point: 205.2 °C
• Appearance: /
• Density: 1.241 g/cm³
• Vapor Pressure: 4.04E-07mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.70±0.20(Predicted)
• CAS DataBase Reference: N-Cbz-Nortropinone(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cbz-Nortropinone(130753-13-8)
• EPA Substance Registry System: N-Cbz-Nortropinone(130753-13-8)

Safety Data

• Hazardous Substances Data: 130753-13-8(Hazardous Substances Data)

Usage

General Description

N-Cbz-Nortropinone is a synthetic chemical compound that belongs to the tropane alkaloid family. It is a derivative of tropinone, and its structure contains a carbobenzyloxy group (Cbz) attached to the nitrogen atom. N-Cbz-Nortropinone is used as an intermediate in the synthesis of various pharmaceuticals and other chemical compounds. Its chemical properties and reactivity make it a valuable building block in the production of drugs and other organic compounds. Studies have shown that N-Cbz-Nortropinone can be used as a precursor for the synthesis of complex molecules with potential medicinal applications, making it an important chemical in the field of organic chemistry and drug development.

InChI:InChI=1/C15H17NO3/c17-14-8-12-6-7-13(9-14)16(12)15(18)19-10-11-4-2-1-3-5-11/h1-5,12-13H,6-10H2

Upstream product

• 25602-68-0 3-oxo-8-azabicyclo[3.2.1]octane hydrochloride 
• 501-53-1 benzyl chloroformate 
• 5632-84-8 nortropinone 
• 96951-89-2 benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate 
• 532-24-1 tropinone 
• 185099-67-6 Boc-tropinone 
• 478837-18-2 3-exo-hydroxy-8-azabicyclo[3.2.1]octane-8carboxylic acid tert-butyl ester 
• 542-05-2 acetonedicarboxylic acid 
• 28957-72-4 N-benzyltropinone 

Downstream Products

• 130753-15-0 benzyl (1S,5R)-(-)-3-trimethylsiloxy-8-azabicyclo<3.2.1>oct-2-ene-8-carboxylate 
• 257628-72-1 3-(1H-indol-3-yl)-8-aza-bicyclo[3.2.1]oct-2-ene-8-carboxylic acid benzyl ester 
• 130753-16-1 methyl (2R,5S)-(-)-1-benzyloxycarbonyl-5-hydroxymethylpyrrolidin-2-ylethanoate 
• 130753-21-8 benzyl (2S,5S)-2-but-1-enyl-5-pent-4-enylpyrrolidine-1-carboxylate 
• 130753-14-9 benzyl (2R,5S)-(-)-2-(hydroxymethyl)-5-(methoxymethoxymethyl)pyrrolidine-1-carboxylate 
• 130753-23-0 benzyl (2R,5S)-2-ethenyl-5-(methoxymethoxymethyl)pyrrolidine-1-carboxylate 
• 130753-17-2 benzyl (2R,5S)-(-)-2-(2-hydroxyethyl)-5-(methoxymethoxymethyl)pyrrolidine-1-carboxylate 
• 130753-19-4 benzyl (2R,5S)-(+)-2-(2-iodoethyl)-5-(methoxymethoxymethyl)pyrrolidine-1-carboxylate 
• 130753-20-7 benzyl (2S,5S)-(-)-2-(methoxymethoxymethyl)-5-pent-4-enylpyrrolidine-1-carboxylate 
• 130753-22-9 benzyl (2S,5S)-2-(but-1-enyl)-5-(4-oxopentyl)pyrrolidine-1-carboxylate 
• 192053-57-9 (2R,5S)-2-Methoxycarbonylmethyl-5-methoxymethoxymethyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 130753-18-3 benzyl (2S,5R)-(-)-2-(methoxymethoxymethyl)-5-(2-p-tolylsulfonyloxyethyl)pyrrolidine-1-carboxylate 
• 799283-75-3 C₂₂H₂₃NO₂ 
• 878167-20-5 C₃₂H₄₀FN₃O₄*ClH 

Relevant articles and documents

CHROMEN-4-ONE DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS DISEASE

The present invention provides novel compounds having the general formula (I) wherein R1 to R6, and m are as described herein, compositions including the compounds and methods of using the compounds.

AN IMPROVED PROCESS FOR THE SYNTHESIS OF ALKYL/ARALKYL (2S)-2-(TERT-BUTOXYCARBONYL)-AMINO-2-[-8-AZABICYCLO[3.2.1]OCT-3-YL]-EXO-ACETATE AND ANALOGS THEREOF: KEY INTERMEDIATES FOR THE PREPARATION OF DPPIV INHIBITORS

An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DPPIV) inhibitors.

UREIDE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES

This invention relates to a pharmaceutical comprising, as an active ingredient, a ureide derivative represented by formula: or a pharmaceutically acceptable salt thereof. The ureide derivative or a pharmaceutically acceptable salt thereof according to the present invention is useful for relieving pain and treating or preventing neuropathic pain.