96951-89-2

Basic information

• Product Name: benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
• Synonyms: benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate
• CAS NO: 96951-89-2
• Molecular Weight: 261.321
• Mol File: 96951-89-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(96951-89-2)
• EPA Substance Registry System: benzyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate(96951-89-2)

Safety Data

• Hazardous Substances Data: 96951-89-2(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 501-33-7 (1R,3R,5S)-8-azabicyclo[3.2.1]octan-3-ol 

Downstream Products

• 130753-13-8 benzyl 3-oxo-8-azabicyclo[3,2,1]octane-8-carboxylate 

Relevant articles and documents

A scalable synthesis of an azabicyclooctanyl derivative, a novel DPP-4 inhibitor

(Chemical Equation Presented) A practical synthetic strategy to a chiral azabicycclooctanyl derivative (1), a potent DPP-4 inhibitor, starting from a commercially available nortropine is described. The stereogenic center of 1 was established employing a modified protocol of Ellman's diastereoselective addition of a benzylic nucleophile to tert-butanesulfinimine. Other key steps include Corey-Chaykovsky reaction, Meinwald rearrangement, and CDMT-promoted amide bond formation involving a sterically hindered amine 2.