258346-69-9

Basic information

• Product Name: 1-(4-TRIFLUOROMETHYLPHENYL)BUTANE-1,3-DIONE
• Synonyms: 1-(4-TRIFLUOROMETHYLPHENYL)BUTANE-1,3-DIONE;1-[4-(TrifluoroMethyl)phenyl]-1,3-butanedione
• CAS NO: 258346-69-9
• Molecular Formula: C₁₁H₉F₃O₂
• Molecular Weight: 230.18
• Product Categories: pharmacetical
• Mol File: 258346-69-9.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 287.669 °C at 760 mmHg
• Flash Point: 101.294 °C
• Appearance: /
• Density: 1.247 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-TRIFLUOROMETHYLPHENYL)BUTANE-1,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-TRIFLUOROMETHYLPHENYL)BUTANE-1,3-DIONE(258346-69-9)
• EPA Substance Registry System: 1-(4-TRIFLUOROMETHYLPHENYL)BUTANE-1,3-DIONE(258346-69-9)

Safety Data

• Hazardous Substances Data: 258346-69-9(Hazardous Substances Data)

Usage

General Description

1-(4-Trifluoromethylphenyl)butane-1,3-dione is a chemical compound with the molecular formula C10H11F3O2. It is a diketone containing a butane-1,3-dione structure with a trifluoromethyl substituted phenyl group. 1-(4-TRIFLUOROMETHYLPHENYL)BUTANE-1,3-DIONE is often used as a building block in organic synthesis and can be found in various pharmaceutical and agrochemical products. It is also used in the production of fragrances and flavoring agents. The trifluoromethyl group enhances the lipophilicity and electron-withdrawing properties of the compound, making it valuable for drug discovery and development. Due to its versatile applications, 1-(4-Trifluoromethylphenyl)butane-1,3-dione is widely used in the chemical industry.

InChI:InChI=1/C11H9F3O2/c1-7(15)6-10(16)8-2-4-9(5-3-8)11(12,13)14/h2-5H,6H2,1H3

Upstream product

• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 141-78-6 ethyl acetate 
• 79-20-9 acetic acid methyl ester 
• 67863-40-5 lithium isopropenolate 
• 329-15-7 4-trifluoromethyl-phenyl acetyl chloride 

Downstream Products

• 1214734-47-0 (Z)-1,5-dihydroxy-5-methyl-1-(4-(trifluoromethyl)phenyl)hex-1-en-3-one 
• 1412902-40-9 3-(4-(trifluoromethyl)phenyl)naphthalen-1-ol 
• 1412902-43-2 4-(4-trifluoromethylphenyl)-2-naphthol 
• 54109-19-2 diethyl (2-oxo-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate 
• 1031900-65-8 1-[4-(trifluoromethyl)phenyl]-2-methylbutane-1,3-dione 
• 60159-60-6 3-methyl-5-nitroisocoumarin 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 583-02-8 ethyl 4-(trifluoromethyl)benzoate 
• 1450605-75-0 5-nitro-3-(4-trifluoromethylphenyl)isoquinolin-1(2H)-one 
• 1450605-85-2 5-amino-3-(4-trifluoromethylphenyl)isoquinolin-1-one 
• 1228180-66-2 3,4-bis(4-(trifluoromethyl)benzoyl)hexane-2,5-dione 
• 859721-81-6 2-(phenylsulfonyl)-1-[4-(trifluoromethyl)phenyl]ethan-1-one 

Relevant articles and documents

I2-Promoted [3+2] Cyclization of 1,3-Diketones with Potassium Thiocyanate: a Route to Thiazol-2(3H)-One Derivatives

An I2-promoted strategy has been developed for the synthesis of thiazol-2(3H)-one derivatives from 1,3-diketones with potassium thiocyanate. This [3+2] cyclization reaction involves C?S and C?N bond formation and exhibits good functional group tolerance. A series of thiazol-2(3H)-one derivatives are obtained in moderate to good yields. (Figure presented.).

Direct synthesis of 2,3,5-trisubstituted pyrroles: via copper-mediated one-pot multicomponent reaction

We have developed a copper-mediated one-pot synthesis of 2,3,5-trisubstituted pyrroles from 1,3-dicarbonyl compounds and acrylates using ammonium acetate as a nitrogen source. The reaction achieves C-C and C-N bond formation and provides an efficient approach to access highly functionalized pyrroles without further raw material preparation. This method is operationally simple, compatible with a wide range of functional groups, and provides the target products in moderate to good yields. This journal is

Pyrazole compound containing N-aryl sulfonate and synthesis and application thereof

The invention discloses a pyrazole compound containing N-aryl sulfonate. A structural formula of the pyrazole compound is shown in the description. Proofed by pharmacological study, the pyrazole compound has the advantages that the activity of cyclooxygenase 2 is inhibited; the high-efficiency inhibition function on the generation of cyclooxygenase 2 due to inflammation mediums is realized, so that the pyrazole compound can be used as an active matter, and the prepared anti-inflammation medicine can be used for treating the inflammations, such as rheumatic arthritis and rheumatalgia, and the diseases and symptoms, such as fevers.