25877-53-6

Basic information

• Product Name: 2-methyl-5-(4-methylphenyl)-1,3,4-oxadiazole
• Synonyms: 1,3,4-oxadiazole, 2-methyl-5-(4-methylphenyl)-; 2-Methyl-5-(4-methylphenyl)-1,3,4-oxadiazole
• CAS NO: 25877-53-6
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 25877-53-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 293.4°C at 760 mmHg
• Flash Point: 130.2°C
• Density: 1.113g/cm³
• Vapor Pressure: 0.00303mmHg at 25°C
• Refractive Index: 1.538
• CAS DataBase Reference: 2-methyl-5-(4-methylphenyl)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-5-(4-methylphenyl)-1,3,4-oxadiazole(25877-53-6)
• EPA Substance Registry System: 2-methyl-5-(4-methylphenyl)-1,3,4-oxadiazole(25877-53-6)

Safety Data

• Hazardous Substances Data: 25877-53-6(Hazardous Substances Data)

Upstream product

• 78-39-7 Triethyl orthoacetate 
• 3619-22-5 p-toluic hydrazide 
• 127-19-5 N,N-dimethyl acetamide 
• 104-87-0 4-methyl-benzaldehyde 
• 59670-16-5 4-Methyl-benzaldehyd- 
• 24994-04-5 5-(p-tolyl)-1H-tetrazole 
• 108-24-7 acetic anhydride 
• 43002-64-8 ethyl 4-methylbenzimidate hydrochloride 
• 1068-57-1 acetic acid hydrazide 
• 54019-08-8 4-methoxy-benzoic acid N'-acetyl-hydrazide 
• 4076-36-2 5-methyl-1,2,3,4-tetrazole 
• 13222-85-0 p-methylbenzoic anhydride 
• 59105-35-0 3-acetyl-5-(4-methoxy-phenyl)-3H-[1,2,3,4]oxathiadiazole 2-oxide 
• 75-36-5 acetyl chloride 

Downstream Products

• 94223-74-2 (4aR,8aS)-3-p-Tolyl-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole 
• 94223-74-2 (4aR,8aR)-3-p-Tolyl-5,6,7,8,8a,9-hexahydro-4aH-[1,2,4]triazolo[4,3-a]indole 
• 94223-59-3 2-(5-p-Tolyl-[1,3,4]oxadiazol-2-ylmethyl)-cyclohexanone 
• 94223-70-8 2-(5-p-Tolyl-[1,3,4]oxadiazol-2-ylmethyl)-cyclohexylamine 
• 94223-62-8 4-Methyl-benzoic acid N'-(5-methyl-4,5-dihydro-3H-pyrrol-2-yl)-hydrazide 
• 94223-66-2 5-Methyl-3-p-tolyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazole 
• 94223-55-9 4-(5-p-Tolyl-[1,3,4]oxadiazol-2-yl)-butan-2-one 

Relevant articles and documents

TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.

One-pot synthesis of 2,5-disubstituted-1,3,4-oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides

Convenient and efficient one pot method for the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N,N-dimethyl amides to 2,5-disubstituted-1,3,4-oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis. Synopsis Convenient and efficient one pot method for the synthesis of 2,5-disubstituted-1,3,4- oxadiazoles based on the reaction of N,N-dimethyl amides with acid hydrazides has been developed. The methodology is applied to a wide range of difference aryl hydrazide and difference N,N-dimethyl amides to 2,5-disubstituted- 1,3,4-oxadiazoles yield the in good to excellent yields. It will be possible wide useful application in synthesis. Copyright

I2-mediated oxidative C-O bond formation for the synthesis of 1,3,4-oxadiazoles from aldehydes and hydrazides

A practical and transition-metal-free oxidative cyclization of acylhydrazones into 1,3,4-oxadiazoles has been developed by employing stoichiometric molecular iodine in the presence of potassium carbonate. The conditions of this cyclization reaction also work well with crude acylhydrazone substrates obtained from the condensation of aldehydes and hydrazides. A series of symmetrical and asymmetrical 2,5-disubstituted (aryl, alkyl, and/or vinyl) 1,3,4-oxadiazoles can be conveniently generated in an efficient and scalable fashion.