258827-42-8

Basic information

• Product Name: (4S,5R)-2,3,4-Trimethyl-5-phenyl-oxazolidine
• Synonyms: (4S,5R)-2,3,4-Trimethyl-5-phenyl-oxazolidine
• CAS NO: 258827-42-8
• Molecular Weight: 191.273
• Mol File: 258827-42-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S,5R)-2,3,4-Trimethyl-5-phenyl-oxazolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (4S,5R)-2,3,4-Trimethyl-5-phenyl-oxazolidine(258827-42-8)
• EPA Substance Registry System: (4S,5R)-2,3,4-Trimethyl-5-phenyl-oxazolidine(258827-42-8)

Safety Data

• Hazardous Substances Data: 258827-42-8(Hazardous Substances Data)

Upstream product

• 299-42-3 ephedrine 
• 75-05-8 acetonitrile 

Downstream Products

• 48141-64-6 (1R,2S)-1-phenyl-2-(ethylmethylamino)propanol 

Relevant articles and documents

Nitriles under palladium-catalyzed hydrogenation conditions as substitutes for aldehydes in the reaction with 1,2-amino alcohols: Formation of 1,3-oxazolidines and reductive N-alkylation

At room temperature, the presence of hydrogen and catalytic amounts of Pd/C induced the formation of 1,3-oxazolidines from nitriles and 1,2-amino alcohols. The subsequent reductive cleavage of the NC-O bond of these heterocycles occurred under the same conditions. Thus, this methodology provides a new one-pot N-alkylation of 19-amino alcohols using nitriles as reagents with yields up to 98%.