259143-04-9

Basic information

• Product Name: 4-Fluoromethylpiperidine
• Synonyms: Piperidine, 4-(fluoromethyl)-;4-Fluoromethylpiperidine;4-(fluoromethyl)piperidine hydrochloride
• CAS NO: 259143-04-9
• Molecular Formula: C₆H₁₂FN
• Molecular Weight: 117.1645832
• Mol File: 259143-04-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 150℃
• Flash Point: 44℃
• Appearance: /
• Density: 0.908
• CAS DataBase Reference: 4-Fluoromethylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoromethylpiperidine(259143-04-9)
• EPA Substance Registry System: 4-Fluoromethylpiperidine(259143-04-9)

Safety Data

• Hazardous Substances Data: 259143-04-9(Hazardous Substances Data)

Usage

General Description

4-Fluoromethylpiperidine is a synthetic chemical compound that belongs to the piperidine class of molecules. It is a substituted piperidine derivative with a fluoromethyl group attached to the piperidine ring. 4-Fluoromethylpiperidine has potential applications in the field of medicinal chemistry and pharmaceutical research, where it may be used as a building block for the synthesis of various bioactive compounds and pharmaceutical drugs. However,

Upstream product

• 122860-33-7 benzyl 4-(hydroxymethyl)piperidine-N-carboxylate 
• 160586-68-5 4-(toluene-4-sulfonyloxymethyl)piperidine-1-carboxylic acid benzyl ester 
• 1257300-07-4 4-(fluoromethyl)-piperidine trifluoroacetate 
• 161975-39-9 tert-butyl 4-(((methylsulfonyl)oxy)methyl)piperidine-1-carboxylate 
• 166815-96-9 N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 6457-49-4 4-piperidinemethanol 
• 259143-03-8 tert-butyl 4-(fluoromethyl)piperidine-1-carboxylate 

Downstream Products

• 259143-05-0 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl 

Relevant articles and documents

Design and Synthesis of Novel N-(2-aminophenyl)benzamide Derivatives as Histone Deacetylase Inhibitors and Their Antitumor Activity Study

Histone deacetylases (HDACs) are promising therapeutic targets for cancer therapy because inhibition of HDACs triggers growth arrest or apoptosis of tumor cells. In the present study, a new series of fluorinated N-(2-aminophenyl)benzamide derivatives were synthesized to investigate potential inhibition of HDACs and associated anticancer activity. Among the synthesized derivatives, compound 24a showed potent inhibitory activity of HDACs and higher antitumor efficacy in human cancer cell lines (HCT-116, MCF-7, and A549) compared with SAHA. Moreover, animal studies demonstrated that compound 24a showed potent in vivo antitumor efficacy in an HCT-116 colon cancer xenograft mouse model.

Synthesis of [18F]FA-4 and [11C]pipzA-4 as radioligands for the high affinity choline uptake system

We have prepared two radiolabelled analogues of hemicholinium-3 (HC-3) as potential in vivo tracers of the sodium dependent high affinity choline uptake (SDHAChU) system. Thus, 4-[1-hydroxy-2-(4-[18F]fluoromethylpiperidinyl)ethyl]-4'-[1-hydroxy-2-(4 -methylpiperidinyl)ethyl]biphenyl ([18F]FA-4) and 4-[1-hydroxy-2-(4-11C]methylpiperazinyl)ethyl]-4'-[1-hydroxy-2-(4 -methylpiperidinyl)]biphenyl ([11C]pipzA-4) have been synthesized. [18F]FA-4 was prepared by reaction of 4-[18F]fluoromethylpiperidine with 4-(α-bromoacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl followed by reduction of the keto groups to alcohols with NaBH4. The total synthesis time was 300 minutes and [18F]FA-4 was obtained with a specific activity of 5.6 GBq/μmol (EOS) and an overall decay corrected radiochemical yield of 3.1 ± 0.6%. [11C]pipzA-4 was prepared by reaction of [11C]methyl triflate with 4-[1-hydroxy-2-piperazinyl)ethyl]-4'-[1-hydroxy-2-(4 -methylpiperidinyl)ethyl]biphenyl. The total synthesis time was 25 minutes and [11C]pipzA-4 was obtained with a specific activity of 13.7 GBq/μmol (EOS) and an overall decay corrected radiochemical yield of 19.5 ± 2.2%.