259143-05-0

Basic information

• Product Name: 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl
• Synonyms: 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl
• CAS NO: 259143-05-0
• Molecular Weight: 450.597
• Mol File: 259143-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl(259143-05-0)
• EPA Substance Registry System: 4-(4-fluoromethylpiperidinylacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl(259143-05-0)

Safety Data

• Hazardous Substances Data: 259143-05-0(Hazardous Substances Data)

Upstream product

• 259143-01-6 4-(2-bromomethyl-(1,3)-dioxalane)-4'-(4-methylpiperidinylacetyl)biphenyl 
• 166815-96-9 N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine 
• 259143-00-5 4-(2-bromomethyl-(1,3)-dioxalane)-4'-(α-bromoacetyl)biphenyl 
• 259143-03-8 tert-butyl 4-(fluoromethyl)piperidine-1-carboxylate 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 4072-67-7 4,4'-bis(bromoacetyl)biphenyl 
• 92-52-4 biphenyl 
• 6457-49-4 4-piperidinemethanol 
• 259143-02-7 4-(α-bromoacetyl)-4'-[(4-methyl-1-piperidinyl)acetyl]biphenyl 
• 259143-04-9 4-piperidinemethylfluoride 

Relevant articles and documents

Synthesis of [18F]FA-4 and [11C]pipzA-4 as radioligands for the high affinity choline uptake system

We have prepared two radiolabelled analogues of hemicholinium-3 (HC-3) as potential in vivo tracers of the sodium dependent high affinity choline uptake (SDHAChU) system. Thus, 4-[1-hydroxy-2-(4-[18F]fluoromethylpiperidinyl)ethyl]-4'-[1-hydroxy-2-(4 -methylpiperidinyl)ethyl]biphenyl ([18F]FA-4) and 4-[1-hydroxy-2-(4-11C]methylpiperazinyl)ethyl]-4'-[1-hydroxy-2-(4 -methylpiperidinyl)]biphenyl ([11C]pipzA-4) have been synthesized. [18F]FA-4 was prepared by reaction of 4-[18F]fluoromethylpiperidine with 4-(α-bromoacetyl)-4'-(4-methylpiperidinylacetyl)biphenyl followed by reduction of the keto groups to alcohols with NaBH4. The total synthesis time was 300 minutes and [18F]FA-4 was obtained with a specific activity of 5.6 GBq/μmol (EOS) and an overall decay corrected radiochemical yield of 3.1 ± 0.6%. [11C]pipzA-4 was prepared by reaction of [11C]methyl triflate with 4-[1-hydroxy-2-piperazinyl)ethyl]-4'-[1-hydroxy-2-(4 -methylpiperidinyl)ethyl]biphenyl. The total synthesis time was 25 minutes and [11C]pipzA-4 was obtained with a specific activity of 13.7 GBq/μmol (EOS) and an overall decay corrected radiochemical yield of 19.5 ± 2.2%.