26055-05-0

Basic information

• Product Name: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-
• Synonyms: L-Phenylalanine,N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl
• CAS NO: 26055-05-0
• Molecular Formula: C20H30N2O5
• Molecular Weight: 378.469
• Mol File: 26055-05-0.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-(26055-05-0)
• EPA Substance Registry System: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-L-leucyl-(26055-05-0)

Safety Data

• Hazardous Substances Data: 26055-05-0(Hazardous Substances Data)

Upstream product

• 130380-48-2 N-tert-Butyloxycarbonyl-L-leucyl-L-phenylalanin-heptylester 
• 3392-09-4 Boc-Leu-ONSu 
• 2462-32-0 L-phenylalanine benzyl ester hydrochloride 
• 63-91-2 L-phenylalanine 
• 66866-44-2 Boc-Leu-O-COO-isoBu 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 15136-32-0 (N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 130380-37-9 L-Phenylalanin-heptylester-hydro-p-toluolsulfonat 
• 13139-16-7 N-tert-butyloxy-isoleucine 
• 88224-00-4 L-phenylalanine allyl ester p-toluenesulfonic acid salt 
• 202265-86-9 (S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionic acid 2-bromo-ethyl ester 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 140834-91-9 (S)-benzyl 2-((S)-2-(tert-butoxycarbonylamino)-4-methylpentanamido)-3-phenylpropanoate 

Downstream Products

• 226922-59-4 (E)-(S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester 
• 1025451-49-3 C₃₃H₄₅N₃O₇ 
• 1025451-42-6 C₃₃H₄₅N₃O₆ 
• 1025451-55-1 C₃₁H₄₆N₄O₇ 
• 1357008-06-0 C₃₈H₅₉N₅O₇S 
• 1357008-66-2 C₃₆H₅₅N₅O₇S 
• 1357008-67-3 C₃₁H₄₇N₅O₅S 
• 1357007-79-4 C₃₁H₄₅N₅O₄S 
• 1357008-00-4 C₃₆H₅₅N₅O₈ 
• 1357008-52-6 C₃₅H₅₃N₅O₈ 
• 1357008-54-8 C₃₀H₄₅N₅O₆ 
• 1357007-70-5 C₃₀H₄₃N₅O₅ 
• 1357008-05-9 C₂₇H₄₃N₃O₆ 
• 1357008-13-9 C₃₇H₅₇N₅O₈ 

Relevant articles and documents

Hydrolysis of polypeptide esters with tetrabutylammonium hydroxide

Tetrabutylammonium hydroxide is effective in hydrolysis of polypeptide esters to the corresponding acids with minimum racemization of the stereogenic centers at the α-positions. It is especially effective in hydrolysis of non-polar polypeptide esters that

α-N-Protected dipeptide acids: A simple and efficient synthesis via the easily accessible mixed anhydride method using free amino acids in DMSO and tetrabutylammonium hydroxide

The importance of dipeptides both in medicinal and pharmacological fields is well documented and many efforts have been made to find simple and efficient methods for their synthesis. For this reason, we have investigated the synthesis of α-N-protected dipeptide acids by reacting the easily accessible mixed anhydride of α-N-protected amino acids with free amino acids under different reaction conditions. The combination of TBA-OH and DMSO has been found to be the best to overcome the low solubility of amino acids in organic solvents. Under these experimental conditions, the homogeneous phase condensation reaction occurs rapidly and without detectable epimerization. The present method is also applicable to side-chain unprotected Tyr, Trp, Glu, and Asp but not Lys. This latter residue is able to engage two molecules of mixed anhydride giving the corresponding isotripeptide. Moreover, the applicability of this protocol for the synthesis of tri- and tetrapeptides has been tested. This approach reduces the need for protecting groups, is cost effective, scalable, and yields dipeptide acids that can be used as building blocks in the synthesis of larger peptides.

Salts responsive nanovesicles through π-Stacking induced self-assembly of backbone modified tripeptides

A set of backbone modified peptides of general formula Boc-Xx-m-ABA-Yy-OMe where m-ABA is meta-aminobenzoic acid and Xx and Yy are natural amino acids such as Phe, Gly, Pro, Leu, Ile, Tyr and Trp etc., are found to self-assemble into soft nanovesicular st