26077-80-5

Basic information

• Product Name: (4-Benzoylphenyl)acetic acid
• Synonyms: (4-Benzoylphenyl)acetic acid;(p-Benzoylphenyl)acetic acid;4-Benzoylbenzeneacetic acid;4-Benzoylphenylacetic acid
• CAS NO: 26077-80-5
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.25
• Mol File: 26077-80-5.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-Benzoylphenyl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (4-Benzoylphenyl)acetic acid(26077-80-5)
• EPA Substance Registry System: (4-Benzoylphenyl)acetic acid(26077-80-5)

Safety Data

• Hazardous Substances Data: 26077-80-5(Hazardous Substances Data)

Usage

Description

(4-Benzoylphenyl)acetic acid is a chemical compound with a molecular formula C15H12O3. It is a white crystalline solid that features a benzoyl group and a phenyl group attached to an acetic acid moiety, providing both aromatic and carboxylic acid functionalities. (4-Benzoylphenyl)acetic acid is commonly used in the pharmaceutical industry as a starting material for the synthesis of various drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs). Additionally, it serves as a reagent in organic synthesis and a building block for the production of other complex organic compounds, making it valuable in medicinal chemistry, drug discovery, and chemical research.

Uses

Used in Pharmaceutical Industry:
(4-Benzoylphenyl)acetic acid is used as a starting material for the synthesis of various drugs, particularly non-steroidal anti-inflammatory drugs (NSAIDs), due to its unique chemical structure and functional groups.
Used in Organic Synthesis:
(4-Benzoylphenyl)acetic acid is used as a reagent in organic synthesis, contributing to the creation of a wide range of complex organic compounds.
Used in Medicinal Chemistry:
(4-Benzoylphenyl)acetic acid is utilized as a building block in medicinal chemistry, playing a role in the development of new pharmaceuticals and therapeutic agents.
Used in Drug Discovery:
(4-Benzoylphenyl)acetic acid is employed in drug discovery processes, aiding researchers in identifying and optimizing potential drug candidates for various medical applications.
Used in Chemical Research:
(4-Benzoylphenyl)acetic acid is used as a component in chemical research, helping scientists explore new reactions, mechanisms, and properties of related compounds.

Upstream product

• 151-50-8 potassium cyanide 
• 874-60-2 4-methyl-benzoyl chloride 
• 71-43-2 benzene 
• 33238-47-0 4-diazoacetyl-benzophenone 
• 39148-58-8 4-benzoylbenzoyl chloride 
• 101-41-7 benzeneacetic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 32752-54-8 4-(bromomethyl)benzophenone 
• 134-84-9 4-Methylbenzophenone 
• 67-56-1 methanol 
• 611-95-0 4-carboxybenzophenone 
• 21192-61-0 2-(4-benzoylphenyl)acetonitrile 
• 24021-68-9 methyl 4-benzoylbenzeneacetate 
• 42327-85-5 (4-benzoyl-phenyl)-acetic acid amide 

Downstream Products

• 37772-31-9 (4-Benzoyl-phenyl)-acetic acid (3R,5S,8R,9S,10S,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester 
• 336099-90-2 3α-[(4-benzoylphenyl)acetyloxy]-6α-acetyloxy-5α-cholestane 
• 251906-46-4 6α,7β-diacetoxy-3α-[(4-benzoylphenyl)acetoxy]-5α-cholestane 
• 336100-22-2 6α,7β-diacetoxy-3α-[(4-benzoylphenyl)acetoxy]-23-(1,1-dimethylpropanoyloxy)-5α-24-norcholane 
• 251906-74-8 4a-[(4-benzoylphenyl)acetoxy]-6α,7β-diacetoxy-23-[tris(1-methylethyl)]silyloxy-5α-24-norcholane 
• 249928-40-3 3α-((4-benzoyl)phenylacetyloxy)-6α-[((1,1-dimethyl)ethyl)dimethylsilyloxy]-5α-cholestane 
• 1146295-91-1 bis-n-butyl-bis{[4-(benzoyl)phenylacetyl]oxy}-stannane 
• 1146295-89-7 tri-n-butyl{[4-(benzoyl)phenylacetyl]oxy}stannane 
• 78212-11-0 (+/-)-[4-(α-hydroxy-benzyl)-phenyl]-acetic acid 
• 24021-68-9 methyl 4-benzoylbenzeneacetate 
• 1356067-69-0 2-(benzyloxy)-1-[(benzyloxy)methyl]ethyl 2-(4-benzylphenyl)acetate 
• 1356067-64-5 2-hydroxy-1-(hydroxymethyl)ethyl 2-(4-benzylphenyl)acetate 

Relevant articles and documents

A reversible and selective inhibitor of monoacylglycerol lipase ameliorates multiple sclerosis

Monoacylglycerol lipase (MAGL) is the enzyme responsible for the inactivation of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibitors show analgesic and tissue-protecting effects in several disease models. However, the few efficient and selective MAGL inhibitors described to date block the enzyme irreversibly, and this can lead to pharmacological tolerance. Hence, additional classes of MAGL inhibitors are needed to validate this enzyme as a therapeutic target. Here we report a potent, selective, and reversible MAGL inhibitor (IC50 = 0.18 mm) which is active in vivo and ameliorates the clinical progression of a multiple sclerosis (MS) mouse model without inducing undesirable CB1-mediated side effects. These results support the interest in MAGL as a target for the treatment of MS.

Photochemistry of benzophenone immobilized in a major groove of DNA: Formation of thermally reversible interstrand cross-link

We here report a highly site and sequence selective formation of an interstrand cross-link of BPU-containing oligomer duplexes. The cross-link was found spontaneously reverted to original oligomers upon heating, providing a new method for the temporary connection of two DNA strands. Copyright

Efficient photodecarboxylation of aroyl-substituted phenylacetic acids in aqueous solution: A general photochemical reaction

Photolysis (254-350 nm) of a variety of aroyl-substituted phenylacetic acids and p-acetylphenylacetic acid in aqueous solution at pH > pK(a) resulted in efficient photodecarboxylation (Φ = 0.2-0.7), to give in most cases a single product arising via the corresponding arylmethyl carbanion, indicating that photodecarboxylation is an efficient and general reaction for these types of compounds.