26103-51-5

Basic information

• Product Name: 3-(Pyrrolidin-1-ylsulphonyl)pyridine
• Synonyms: 1-(Pyridin-3-ylsulphonyl)pyrrolidine;3-(Pyrrolidin-1-ylsulphonyl)pyridine;3-(Pyrrolidin-1-ylsulphonyl)pyridine 98%;1-(Pyridin-3-ylsulfonyl)pyrrolidine;3-(1-pyrrolidinylsulfonyl)pyridine;3-(Pyrrolidin-1-ylsulfonyl)pyridine;3-[(Pyrrolidin-1-yl)sulphonyl]pyridine98%
• CAS NO: 26103-51-5
• Molecular Formula: C9H12N2O2S
• Molecular Weight: 212.26878
• Product Categories: blocks;Pyridines;Sulfonamides
• Mol File: 26103-51-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 368.367 °C at 760 mmHg
• Flash Point: 176.582 °C
• Appearance: /
• Density: 1.325 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(Pyrrolidin-1-ylsulphonyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Pyrrolidin-1-ylsulphonyl)pyridine(26103-51-5)
• EPA Substance Registry System: 3-(Pyrrolidin-1-ylsulphonyl)pyridine(26103-51-5)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 26103-51-5(Hazardous Substances Data)

Usage

General Description

3-(Pyrrolidin-1-ylsulphonyl)pyridine, also known as PPS, is a chemical compound with a molecular formula C11H15NO2S. It is a sulphonamide derivative with a pyridine ring and a pyrrolidine side chain. PPS is used as a building block in organic synthesis and pharmaceutical research, particularly in the development of new drugs. It has been studied for its potential anti-inflammatory and anti-cancer properties, and as a potential inhibitor of heat shock protein 90 (Hsp90) in cancer cells. PPS is a versatile compound with a range of potential applications, and ongoing research continues to explore its pharmacological and therapeutic potential.

InChI:InChI=1/C9H12N2O2S/c12-14(13,11-6-1-2-7-11)9-4-3-5-10-8-9/h3-5,8H,1-2,6-7H2

Upstream product

• 636-73-7 3-pyridinesulfonic acid 
• 7335-06-0 1-ethylpyrrolidine 
• 65227-53-4 pyridine-3-sulfonohydrazide 
• 16133-25-8 Pyridine-3-sulfonyl chloride 
• 626-55-1 3-Bromopyridine 
• 123-75-1 pyrrolidine 

Downstream Products

• 88184-94-5 Phenyl-[3-(pyrrolidine-1-sulfonyl)-pyridin-4-yl]-methanol 

Relevant articles and documents

Iodine-catalyzed sulfonylation of sulfonyl hydrazides with: Tert -amines: A green and efficient protocol for the synthesis of sulfonamides

This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C-N bonds. In this reaction, molecular iodine was used as the catalyst and t-butyl hydroperoxide was used as the oxidant.

DABCO-bis (sulfur dioxide), DABSO, as a convenient source of sulfur dioxide for organic synthesis: Utility in sulfonamide and sulfamide preparation

The charge-transfer complex generated from the combination of DABCO and sulfur dioxide, DABSO, is a bench-stable colorless solid suitable for use in organic synthesis as a replacement for gaseous sulfur dioxide. The complex can be combined with Grignard reagents to form sulfinates, which can then be converted in situ to a series of sulfonamides. Alternatively, reaction with anilines and iodine leads to the formation of a series of sulfamides. Cheletropic addition between DABSO and 2,3-dimethylbutadiene provides the corresponding sulfolene.

Regioselective Lithiation of 3-Pyridylsulfonic Acid Derivatives: A Convenient Route to Various New 4-Substituted 3-Pyridylsulfonamides

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