264916-06-5

Basic information

• Product Name: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE
• Synonyms: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE;5-Amino-1,3-dihydro-2H-isoindole-2-carboxylic acid tert-butyl ester;5-Amino-1,3-dihydroisoindole-2-carboxylic acid tert-butyl ester;5-Amino-2-(tert-butoxycarbonyl)isoindoline;5-Aminoisoindoline-2-carboxylic acid tert-butyl ester;tert-butyl 5-aMinoisoin;tert-butyl 5-aMino-2,3-dihydro-1H-isoindole-2-carboxylate
• CAS NO: 264916-06-5
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.29
• Mol File: 264916-06-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 376.304 °C at 760 mmHg
• Flash Point: 181.382 °C
• Appearance: /
• Density: 1.177
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.582
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.76±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE(264916-06-5)
• EPA Substance Registry System: TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE(264916-06-5)

Safety Data

• Hazardous Substances Data: 264916-06-5(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE is a chemical compound with the molecular formula C15H18N2O2. It is a tert-butyl ester derivative of 5-aminoisatin, an intermediate in the synthesis of various pharmaceuticals. The compound has been studied for its potential biological activities, including its role as a potential anti-tumor agent and as a pharmacological chaperone for the treatment of lysosomal storage disorders. Additionally, it has been investigated for its potential use in the synthesis of novel heterocyclic compounds with biological activities. Overall, TERT-BUTYL 5-AMINOISOINDOLINE-2-CARBOXYLATE shows promise as a versatile compound with various potential applications in medicinal chemistry and pharmaceutical research.

InChI:InChI=1/C13H18N2O2/c1-13(2,3)17-12(16)15-7-9-4-5-11(14)6-10(9)8-15/h4-6H,7-8,14H2,1-3H3

Upstream product

• 400727-63-1 tert-butyl 5-nitroisoindoline-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 46053-72-9 5-nitroisoindoline 
• 496-12-8 isoindoline 
• 832-51-9 1-(1,3-dihydro-2H-isoindol-2-yl)-2,2,2-trifluoroethanone 
• 1059172-96-1 2,2,2-trifluoro-1-(5-nitroisoindolin-2-yl)ethan-1-one 

Downstream Products

• 945488-70-0 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-methoxyphenyl)-β-alanine 
• 945488-73-3 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopropoxyphenyl)-β-alanine 
• 945488-71-1 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-ethoxyphenyl)-β-alanine 
• 945488-77-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(3,4-dimethoxyphenyl)-β-alanine 
• 945488-72-2 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-propoxyphenyl)-β-alanine 
• 945488-75-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isobutyloxyphenyl)-β-alanine 
• 945488-74-4 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-butoxyphenyl)-β-alanine 
• 945488-76-6 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-D,L-β-(p-isopentyloxyphenyl)-β-alanine 
• 807627-84-5 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine methyl ester 
• 807627-86-7 N-[4-(N-Boc-isoindolin-5-yl)amino-4-oxobutyryl]-β-phenyl-β-alanine 
• 264916-07-6 2-tert-butoxycarbonyl-5-(2-nitrophenylamino)isoindoline 
• 1264924-32-4 1,1-dimethylethyl 1,3-dihydro-5-[[5-methoxy-6-(4-methylphenyl)-4-pyrimidinyl]amino]-2H-isoindole-2-carboxylate 
• 1264924-35-7 4-[(2,3-dihydro-1H-isoindol-5-yl)amino]-6-(4-methylphenyl)-5-pyrimidinol 
• 1456885-52-1 4-((2-ethylisoindolin-5-yl)carbamoyl)benzoic acid trifluoroacetic acid 

Relevant articles and documents

THIENODIAZEPINE DERIVATIVES AND APPLICATION THEREOF

The present invention relates to a class of thienodiazepine derivatives and an application thereof in the preparation of a drug for the treatment of diseases associated with bromodomain and extra-terminal (BET) Bromodomain inhibitors. Specifically, the present invention relates to compounds represented by formulas (I) and (II), as well as pharmaceutically acceptable salts thereof.

4, 5, 6-TRISUBSTITUTED PYRIMIDINE DERIVATIVES AS FACTOR IXA INHIBITORS

The present invention relates to novel heterocyclic compounds of Formulae (I): (Chemical formula should be inserted here as it appears on abstract in paper form) Formula (I) as disclosed herein, or a pharmaceutically acceptable salt, solvate, ester, prodrug or stereoisomer thereof. Also disclosed are pharmaceutical compositions comprising said compounds, and methods for using said compounds for treating or preventing a thromboembolic disorder.

PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a] PYRIDINE DERIVATIVES

This application relates to compounds of the general Formula I and salts thereof, wherein X, R1A, R1B, R2, R3, R4, and R5 are as defined herein. The application also relates to compositions and methods of treatment of hyperproliferative diseases or disorders.