26717-53-3

Basic information

• Product Name: 2(5H)-Furanone, 4-(4-chlorophenyl)-
• CAS NO: 26717-53-3
• Molecular Formula: C10H7ClO2
• Molecular Weight: 194.617
• Mol File: 26717-53-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 4-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 4-(4-chlorophenyl)-(26717-53-3)
• EPA Substance Registry System: 2(5H)-Furanone, 4-(4-chlorophenyl)-(26717-53-3)

Safety Data

• Hazardous Substances Data: 26717-53-3(Hazardous Substances Data)

Upstream product

• 1679-18-1 4-Chlorophenylboronic acid 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 81187-88-4 3-(4-chlorophenyl)-3-butenoic acid 
• 45941-96-6 2-(4-chlorophenyl)-3-hydroxypropene 
• 81187-90-8 (Z)-4-Bromo-3-(4-chloro-phenyl)-but-2-enoic acid 
• 99-91-2 para-chloroacetophenone 
• 81187-89-5 (E)-3-(4-chlorophenyl)but-2-enoic acid 
• 21133-98-2 ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate 
• 81187-86-2 ethyl 3-(4-chlorophenyl)-2-butenoate 
• 476471-06-4 4-(4-chlorophenyl)-2-methoxytetrahydrofuran 
• 471931-08-5 4-(p-toluenesulfonyloxy)-2(5H)-furanone 
• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 
• 106201-12-1 methyl 3-(4-chlorophenyl)-2-butenoate 
• 81187-91-9 (Z)-4-amino-3-(4-chlorophenyl)but-2-enoic acid 

Downstream Products

• 95412-22-9 4-(4-Chloro-phenyl)-5-[1-thiophen-2-yl-meth-(Z)-ylidene]-5H-furan-2-one 
• 95412-20-7 (Z)-5-benzylidene-4-(4-chlorophenyl)-5H-furan-2-one 
• 26717-54-4 β-(4-chlorophenyl)-γ-butyrolactone 
• 147224-51-9 β-(R)-(p-chlorophenyl)-γ-butyrolactone 
• 95412-16-1 (Z)-3-(4-Chloro-phenyl)-4-hydroxy-but-2-enoic acid methylamide 
• 185342-39-6 5-Bromo-4-(4-chloro-phenyl)-5H-furan-2-one 

Relevant articles and documents

Palladium-catalyzed hydrodehalogenation of butenolides: An efficient and sustainable access to β-arylbutenolides

Several α-unsubstituted β-arylbutenolides have been prepared in 69–92% yield by reductive dehalogenation of α-halo-β-arylbutenolides. The latter were assembled in a single-step from α,β-dihalobutenolides, which are accessible on a large-scale from biomass-derived furfural. Our dehalogenation protocol is illustrated by a new synthesis of the marine antibiotics rubrolide E and F, and 3″-bromorubrolide F.

Hg/Pt-catalyzed conversion of bromo alkynamines/alkynols to saturated and unsaturated γ-butyrolactams/lactones via intramolecular electrophilic cyclization

Convenient and general Hg(ii)/Pt(iv) catalyzed syntheses of γ-butyrolactams and α,β-unsaturated γ-butyrolactones/lactams are described via intramolecular electrophilic cyclizations of bromoalkynes with tosylamino and hydroxyl tethers. The reaction features the use of wet solvents, the exclusion of any base and additive, mild conditions and practical yields. We also synthesised few chiral lactams through this pathway. Additionally, it is shown that the NHTs group distanced further from the homopropargylic position assists regioselective bromoalkyne hydration to yield useful α-bromoketones. Furthermore, Boc protected bromo homo propargyl amines undergo 6-endo-dig cyclization through Boc oxygen to give bromomethylene substituted oxazinones.

Palladium-catalyzed cross-coupling reactions of 4-tosyl-2(5H)-furanone with boronic acids: A facile and efficient route to generate 4-substituted 2(5H)-furanones

An efficient and facile synthesis of 4-substituted 2(5H)-furanones using palladium catalyzed cross-coupling reactions between 4-tosyl-2(5H)-furanone and boronic acids is reported herein.