81187-86-2

Basic information

• Product Name: 2-Butenoic acid, 3-(4-chlorophenyl)-, ethyl ester, (2E)-
• Synonyms: (E)-ethyl-3-(4-chlorophenyl)-but-2-enoate;(E)-ethyl 3-(4-chlorophenyl)but-2-enoate;ethyl (E)-3-(4-chlorophenyl)but-2-enoate;ethyl (E)-3-(4-chlorophenyl)-2-butenoate;ethyl 3-(4-chlorophenyl)but-2-enoate
• CAS NO: 81187-86-2
• Molecular Formula: C12H13ClO2
• Molecular Weight: 224.687
• Mol File: 81187-86-2.mol
• Article Data: 47

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 3-(4-chlorophenyl)-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 3-(4-chlorophenyl)-, ethyl ester, (2E)-(81187-86-2)
• EPA Substance Registry System: 2-Butenoic acid, 3-(4-chlorophenyl)-, ethyl ester, (2E)-(81187-86-2)

Safety Data

• Hazardous Substances Data: 81187-86-2(Hazardous Substances Data)

Upstream product

• 21133-98-2 ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate 
• 1195-42-2 N-cyclohexylisopropylamine 
• 57025-65-7 2-(trimethylsilyl)butanoic acid 
• 99-91-2 para-chloroacetophenone 
• 32400-20-7 lithium cyclohexylisopropylamide 
• 106-39-8 bromochlorobenzene 
• 623-70-1 ethyl (E)-crotonate 
• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 
• 4755-77-5 Ethyl oxalyl chloride 
• 97025-43-9 ethyl 3-(toluene-4-sulfonyloxy)but-2-enoate 
• 1679-18-1 4-Chlorophenylboronic acid 
• 1474-78-8 triethyl phosphonoformate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 106201-12-1 methyl 3-(4-chlorophenyl)-2-butenoate 
• 153805-70-0 (Z)-ethyl 4-bromo-3-(4-chlorophenyl)but-2-enoate 
• 114566-93-7 ethyl 4-bromo-3-(4-chlorophenyl)-2-butenoate 
• 1376710-77-8 (E)-3-(4-chlorophenyl)-N-methoxy-N-methylbut-2-enamide 
• 1446100-81-7 3-(4-chlorophenyl)-3-methylindan-1-one 
• 1446100-82-8 3-(4-chlorophenyl)-3,6-dimethylindan-1-one 
• 1446100-84-0 3-(4-chlorophenyl)-5,6-dimethoxy-3-methylindan-1-one 
• 93404-36-5 (2E)-3-(4'-chlorophenyl)but-2-en-1-ol 
• 1134201-72-1 (-)-(R)-3-(4-methoxyphenyl)butan-1-ol 
• 1712-70-5 1-chloro-4-(1-methylethenyl)-benzene 
• 26717-53-3 4-(4-chlorophenyl)furan-2(5H)-one 

Relevant articles and documents

Palladium-Catalyzed Allyl-Allyl Reductive Coupling of Allylamines or Allylic Alcohols with H2as Sole Reductant

Catalytic carbon-carbon bond formation building on reductive coupling is a powerful method for the preparation of organic compounds. The identification of environmentally benign reductants is key for establishing an efficient reductive coupling reaction. Herein an efficient strategy enabling H2 as the sole reductant for the palladium-catalyzed allyl-allyl reductive coupling reaction is described. A wide range of allylamines and allylic alcohols as well as allylic ethers proceed smoothly to deliver the C-C coupling products under 1 atm of H2. Kinetic studies suggested that the dinuclear palladium species was involved in the catalytic cycle.

Metal-Free Hydropyridylation of Thioester-Activated Alkenes via Electroreductive Radical Coupling

An electrochemical hydropyridylation of thioester-activated alkenes with 4-cyanopyridines has been developed. The reactions experience a tandem electroreduction of both substrates on the cathode surface, protonation, and radical cross-coupling process, resulting in a variety of valuable pyridine variants, which contain a tertiary and even a quaternary carbon at the α-position of pyridines, in high yields. The employment of thioesters to the conjugated alkenes enables no requirement of catalyst and high temperature, representing a highly sustainable synthetic method.

Cobalt-Catalyzed Asymmetric 1,4-Hydroboration of Enones with HBpin

Herein, a series of new 8-OIQ cobalt complexes were synthesized and used for cobalt-catalyzed chemo- and enantioselective 1,4-hydroboration of enones with HBpin to access chiral β,β-disubstituted ketones with good to excellent chemo- and enantioselectivties. This protocol is operationally simple and shows a broad substrate scope.