2683-49-0

Basic information

• Product Name: 4-Aminopyridine-2,6-dicarboxylic acid
• Synonyms: 4-Aminopyridine-2,6-dicarboxylic acid;2,6-Pyridinedicarboxylic acid, 4-aMino;4-AMinopyridine-2,6-dicarboxylic hydrochloride salt
• CAS NO: 2683-49-0
• Molecular Formula: C₇H₆N₂O₄
• Molecular Weight: 182.14
• Mol File: 2683-49-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 618.917 °C at 760 mmHg
• Flash Point: 328.109 °C
• Appearance: /
• Density: 1.656 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.698
• Storage Temp.: 2-8°C(protect from light)
• PKA: 0.77±0.50(Predicted)
• CAS DataBase Reference: 4-Aminopyridine-2,6-dicarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Aminopyridine-2,6-dicarboxylic acid(2683-49-0)
• EPA Substance Registry System: 4-Aminopyridine-2,6-dicarboxylic acid(2683-49-0)

Safety Data

• Hazardous Substances Data: 2683-49-0(Hazardous Substances Data)

Usage

General Description

4-Aminopyridine-2,6-dicarboxylic acid is a chemical compound with the molecular formula C7H7NO4. It is also known as kynurenic acid and is a derivative of the amino acid L-tryptophan. 4-Aminopyridine-2,6-dicarboxylic acid is found in the brain and has been shown to have neuroprotective and neurotoxic properties. It acts as an antagonist for the glycine site of the N-methyl-D-aspartate (NMDA) receptor, and it is considered to be a potential therapeutic target for disorders such as epilepsy, schizophrenia, and neurodegenerative diseases. Additionally, 4-Aminopyridine-2,6-dicarboxylic acid has been found to have anti-inflammatory and antioxidant effects, and its potential use in the treatment of various neurological disorders is currently being studied.

InChI:InChI=1/C7H6N2O4/c8-3-1-4(6(10)11)9-5(2-3)7(12)13/h1-2H,(H2,8,9)(H,10,11)(H,12,13)

Upstream product

• 150730-41-9 dimethyl 4-aminopyridine-2,6-dicarboxylate 
• 184870-12-0 chelidamic acid 
• 179022-67-4 4-(acetylamino)-2,6-dimethylpyridine 
• 138-60-3 chelidamic acid 
• 71022-75-8 4-chloropyridine-2,6-dicarbonyl dichloride 
• 499-51-4 Chelidamic acid 
• 5371-70-0 dimethyl 4-chloro-2,6-pyridinedicarboxylate 
• 4722-94-5 4-chloro-2,6-pyridinedicarboxylic acid 
• 162102-82-1 4-acetylamino-pyridine-2,6-dicarboxylic acid 

Downstream Products

• 73353-51-2 C₁₅H₁₈ClNO₇*C₈H₁₁N*ClHO₄ 
• 71124-59-9 C₁₅H₁₈ClNO₇*C₇H₉N*ClHO₄ 
• 71124-58-8 C₁₅H₁₈ClNO₇*C₇H₉N*CHNS 
• 504-24-5 4-aminopyridine 
• 63897-10-9 4-nitro-pyridine-2,6-dicarboxylic acid 
• 499-51-4 Chelidamic acid 

Relevant articles and documents

A Novel Reagent for Labelling Macromolecules with Intensely Luminescent Lanthanide Complexes

A novel bifunctional chelator, 4-iodoacetamidodipicolinic acid, has been synthesized in three steps starting with chelidamic acid, and used to prepare protein conjugates that form stable and intensely luminescent complexes with Tb(III) and Eu(III).The excited state lifetime of Tb(III) complexes with this reagent was 1.25 ms, permitting its use for ultrasensitive time-resolved luminescence assays.

Selective cytotoxicity and luminescence imaging of cancer cells with a dipicolinato-based EuIII complex

Four new species [Ln(dipicNH2)3]3- (Ln = LaIII, EuIII, GdIII, TbIII), with the ligand dipicNH22- (dipic = dipicolinato), were synthesized. Incubation of the EuIII complex with glioma NG97 and pancreatic cancer PANC1 cells showed that it penetrates the cell membrane and can be used to image the cells, while also being moderately cytotoxic.

Cation Complexing Properties of Synthetic Macrocyclic Polyether-Diester Ligands Containing the Pyridine Subcyclic Unit

Ten new macrocyclic polyether-diester compounds containing a pyridine subcyclic unit substituted in the 4 position with chloro or methoxy groups have been prepared.These compounds along with their unsubstituted pyridine analogues form strong complexes wit