26934-87-2 Usage
Description
HT-2 Toxin is a trichothecene group mycotoxin, which is the 4-hydroxy analogue of T-2 Toxin. It is known for its ability to induce DNA damage and cell death upon prolonged administration. The chemical properties of HT-2 Toxin present as a white powder.
Uses
Used in Research and Development:
HT-2 Toxin is used as a research compound for studying its effects on DNA damage and cell death. This application is crucial for understanding the mechanisms behind its toxic properties and potential implications in various fields, such as toxicology and pharmacology.
Used in Agricultural and Food Safety:
HT-2 Toxin is used as a reference material in the development and validation of analytical methods for detecting and quantifying mycotoxins in agricultural products and the food supply. This helps ensure the safety and quality of the food we consume.
Used in Pharmaceutical Industry:
HT-2 Toxin can be used as a starting material or a reference compound in the development of drugs targeting trichothecene group mycotoxins. This application is important for creating potential treatments or antidotes for mycotoxin poisoning.
Used in Environmental Monitoring:
HT-2 Toxin is used as a monitoring tool to assess the presence and levels of mycotoxins in the environment, particularly in areas with a high risk of fungal contamination. This helps in identifying potential health risks and implementing preventive measures.
Used in Educational Purposes:
HT-2 Toxin can be used as a teaching aid in educational institutions to demonstrate the properties and effects of mycotoxins, as well as their role in food safety and environmental health.
Check Digit Verification of cas no
The CAS Registry Mumber 26934-87-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,9,3 and 4 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 26934-87:
(7*2)+(6*6)+(5*9)+(4*3)+(3*4)+(2*8)+(1*7)=142
142 % 10 = 2
So 26934-87-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H32O8/c1-11(2)6-16(24)29-14-8-21(9-27-13(4)23)15(7-12(14)3)30-19-17(25)18(26)20(21,5)22(19)10-28-22/h7,11,14-15,17-19,25-26H,6,8-10H2,1-5H3/t14-,15+,17+,18+,19+,20+,21+,22+/m0/s1
26934-87-2Relevant articles and documents
HT-2 toxin 4-glucuronide as new T-2 toxin metabolite: Enzymatic synthesis, analysis, and species specific formation of T-2 and HT-2 toxin glucuronides by rat, mouse, pig, and human liver microsomes
Welsch, Tanja,Humpf, Hans-Ulrich
, p. 10170 - 10178,9 (2020/09/15)
Glucuronides of the mycotoxin T-2 toxin and its phase I metabolite HT-2 toxin are important phase II metabolites under in vivo and in vitro conditions. Since standard substances are essential for the direct quantitation of these glucuronides, a method for the enzymatic synthesis of T-2 and HT-2 toxin glucuronides employing liver microsomes was optimized. Structure elucidation by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry revealed that besides T-2 toxin glucuronide and HT-2 toxin 3-glucuronide also the newly identified isomer HT-2 toxin 4-glucuronide was formed. Glucuronidation of T-2 and HT-2 toxin in liver microsomes of rat, mouse, pig, and human was compared and metabolites were analyzed directly by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). A distinct, species specific pattern of glucuronidation of T-2 and HT-2 toxin was observed with interesting interindividual differences. Until recently, glucuronides have frequently been analyzed indirectly by quantitation of the aglycone after enzymatic cleavage of the glucuronides by β-glucuronidase. Therefore, the hydrolysis efficiencies of T-2 and HT-2 toxin glucuronides using β-glucuronidases from Helix pomatia, bovine liver, and Escherichia coli were compared.
