269396-59-0 Usage
General Description
"Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid" is a chemical compound that is commonly used in the field of medicinal chemistry. It is a derivative of the amino acid valine, which is important for protein synthesis and muscle growth. The compound contains a Boc (tert-butyloxycarbonyl) protecting group, which is commonly used in organic synthesis to protect functional groups from unwanted reactions. The presence of a difluoro-phenyl group in the compound's structure makes it potentially useful for targeting specific biological pathways or interactions. Overall, "Boc-(R)-3-Amino-4-(3,4-difluoro-phenyl)-butyric acid" is a valuable molecule for designing and synthesizing new drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 269396-59-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,3,9 and 6 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 269396-59:
(8*2)+(7*6)+(6*9)+(5*3)+(4*9)+(3*6)+(2*5)+(1*9)=200
200 % 10 = 0
So 269396-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H19F2NO4/c1-15(2,3)22-14(21)18-10(8-13(19)20)6-9-4-5-11(16)12(17)7-9/h4-5,7,10H,6,8H2,1-3H3,(H,18,21)(H,19,20)/t10-/m1/s1
269396-59-0Relevant articles and documents
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Xu, Jinyou,Ok, Hyun O.,Gonzalez, Edward J.,Colwell Jr., Lawrence F.,Habulihaz, Bahanu,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Marsilio, Frank,Patel, Reshma A.,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Parmee, Emma R.
, p. 4759 - 4762 (2007/10/03)
Modification of in-house screening lead β-aminoacyl proline 8 gave an equipotent thiazolidide 9. Extensive SAR studies on the phenyl ring of 9 led to the discovery of a novel series of potent and selective DP-IV inhibitors. Introduction of a fluorine at the 2-position proved to be crucial for the potency of this series. The 2,5-difluoro (22q) and 2,4,5-trifluoro (22t) analogues were potent inhibitors of DP-IV (IC50 = 270, 119 nM, respectively).
