270596-43-5 Usage
General Description
FMOC-(S)-3-Amino-4-(4-Chloro-Phenyl)-Butyric Acid is a specialized compound used primarily in the realm of organic chemistry. It is categorised as an amino acid derivative with a protective Fmoc group, which is widely employed in solid-phase peptide synthesis (SPPS). The presence of a 4-chloro-phenyl group attached to the butyric acid chain alters its chemical properties. It is important for chemists and researchers working in drug discovery and peptide related studies. Despite its general use in organic synthesis, it is crucial to handle this chemical carefully due to the presence of chlorine, which can be hazardous in certain conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 270596-43-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,7,0,5,9 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 270596-43:
(8*2)+(7*7)+(6*0)+(5*5)+(4*9)+(3*6)+(2*4)+(1*3)=155
155 % 10 = 5
So 270596-43-5 is a valid CAS Registry Number.
InChI:InChI=1/C25H22ClNO4/c26-17-11-9-16(10-12-17)13-18(14-24(28)29)27-25(30)31-15-23-21-7-3-1-5-19(21)20-6-2-4-8-22(20)23/h1-12,18,23H,13-15H2,(H,27,30)(H,28,29)/t18-/m0/s1
270596-43-5Relevant articles and documents
Solution phase synthesis of β-peptides using micro reactors
Watts, Paul,Wiles, Charlotte,Haswell, Stephen J,Pombo-Villar, Esteban
, p. 5427 - 5439 (2007/10/03)
The synthesis of β-peptides has been successfully performed using a borosilicate glass micro reactor, in which a network of channels has been produced using a photolithographic and wet etching method. The reagents were mobilised by electroosmotic flow (EOF). The micro reactor was initially evaluated using a carbodiimide coupling reaction to form a dipeptide. The methodology has been extended such that the peptides may also be produced via the pentafluorophenyl ester derivatives of amino acids. It was found that performing the pentafluorophenyl ester reactions in the micro reactor resulted in an increase in the reaction efficiency over the traditional batch method. We postulate that the enhancement in rate of reaction is an electrochemical phenomenon, due to the reaction being performed in an electric field, which is unique to micro reactor systems. It has also been demonstrated that selective deprotection of the resultant dipeptides can be achieved. This approach has been used in the synthesis of a tripeptide.