2706-50-5

Basic information

• Product Name: rac AMphetaMine Hydrochloride
• Synonyms: rac AMphetaMine Hydrochloride;rac AMphetaMine Hydrochloride (1.0 Mg/ML in Methanol);rac AMphetaMine Hydrochloride (100 μg/ML in Methanol);1-phenylpropan-2-amine hydrochloride;SEVKYLYIYIKRSW-UHFFFAOYSA-N
• CAS NO: 2706-50-5
• Molecular Formula: C₉H₁₃N*ClH
• Molecular Weight: 171.66716
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 2706-50-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 127-129?C
• Boiling Point: 201.5°Cat760mmHg
• Flash Point: 87.4°C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Controlled Substance, -20?C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: rac AMphetaMine Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: rac AMphetaMine Hydrochloride(2706-50-5)
• EPA Substance Registry System: rac AMphetaMine Hydrochloride(2706-50-5)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 2706-50-5(Hazardous Substances Data)

Usage

Description

rac AMphetamine Hydrochloride, also known as racephedrine, is a psychoactive drug that belongs to the phenethylamine class. It is a central nervous system (CNS) stimulant and an anorexic agent, which means it can suppress appetite. rac AMphetaMine Hydrochloride is a white solid and is classified as a controlled substance due to its stimulant properties.

Uses

Used in Pharmaceutical Industry:
rac AMphetamine Hydrochloride is used as a CNS stimulant for the treatment of attention deficit hyperactivity disorder (ADHD) and narcolepsy. Its stimulant effects help increase focus, attention, and reduce impulsiveness in individuals with ADHD. Additionally, it is used to promote wakefulness in patients suffering from narcolepsy, a condition characterized by excessive daytime sleepiness.
Used in Weight Loss Applications:
In the weight loss industry, rac AMphetamine Hydrochloride is used as an anorexic agent to suppress appetite and promote weight loss. Its ability to decrease hunger and increase metabolism makes it a potential treatment option for obesity and related health conditions.
Used in Research and Development:
rac AMphetamine Hydrochloride is also utilized in the research and development of new medications and therapies. Its psychoactive properties and effects on the CNS make it a valuable compound for studying the mechanisms of addiction, mental health disorders, and the development of novel treatments for various conditions.

Safety Profile

Poison by subcutaneous,intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.See other amphetamine entries.

Upstream product

• 7761-64-0 diethyl (1-phenylpropan-2-yl)phosphoramidate 
• 345308-53-4 C₂₁H₂₂NOP 
• 31731-87-0 1-methyl-2-phenylethylmagnesium bromide 
• 300-57-2 allylbenzene 
• 82572-07-4 C₂₁H₂₀NOP 
• 13213-36-0 1-phenylpropan-2-one oxime 
• 51-64-9 dexamfetamine 
• 103-65-1 phenylpropane 
• 61380-47-0 (±)-1-phenylpropanyl-2-yl methansulfonate 
• 698-87-3 3-phenyl-2-propanol 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 3198-15-0 (1R,2S)-(-)-norephedrine hydrochloride 
• 39861-30-8 2-chloro-1-methyl-2-phenyl-ethylamine; hydrochloride 

Downstream Products

• 6338-74-5 4-methyl-N-(1-phenylpropan-2-yl)benzenesulfonamide 
• 33061-37-9 N-(1-Methyl-2-phenylethyl)harnstoff 
• 103994-79-2 3-[(1-Methyl-2-phenyl-ethylamino)-methyl]-5-pyridin-4-yl-3H-[1,3,4]oxadiazole-2-thione; hydrochloride 
• 17590-01-1 amphetaminil 
• 22293-47-6 3-(α-methylphenethyl)sydnone imine 

Relevant articles and documents

Synthesis of α-Substituted Primary Benzylamines through Copper-Catalyzed Cross-Dehydrogenative Coupling

A copper-catalyzed route to α-substituted, primary benzylamines by C-H functionalization of alkylarenes is described. The method directly affords the amine hydrochloride salt. Catalyst loadings down to 0.1 mol % in combination with scalability, insensitivity to air and moisture, and no need for column chromatography makes the procedure highly practical. The facile synthesis of the racemate of a blockbuster drug highlights the relevance for the development of pharmaceuticals. Preliminary mechanistic data are also included.

Sustainable organophosphorus-catalysed Staudinger reduction

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.

Stereoretentive Deuteration of α-Chiral Amines with D2O

We present the direct and stereoretentive deuteration of primary amines using Ru-bMepi (bMepi = 1,3-(6′-methyl-2′-pyridylimino)isoindolate) complexes and D2O. High deuterium incorporation occurs at the α-carbon (70-99%). For α-chiral amines, complete retention of stereochemistry is achieved when using an electron-deficient Ru catalyst. The retention of enantiomeric purity is attributed to a high binding affinity of an imine intermediate with ruthenium, as well as to a fast H/D exchange relative to ligand dissociation.