2732-17-4

Basic information

• Product Name: 7-hydroxy-8-methyl-2H-chromen-2-one
• CAS NO: 2732-17-4
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.1687
• Mol File: 2732-17-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 374.4°C at 760 mmHg
• Flash Point: 172.9°C
• Density: 1.336g/cm³
• Vapor Pressure: 3.88E-06mmHg at 25°C
• Refractive Index: 1.622
• CAS DataBase Reference: 7-hydroxy-8-methyl-2H-chromen-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-8-methyl-2H-chromen-2-one(2732-17-4)
• EPA Substance Registry System: 7-hydroxy-8-methyl-2H-chromen-2-one(2732-17-4)

Safety Data

• Hazardous Substances Data: 2732-17-4(Hazardous Substances Data)

Upstream product

• 107-31-3 Methyl formate 
• 608-25-3 2-methylbenzene-1,3-diol 
• 141-78-6 ethyl acetate 
• 34780-29-5 3-oxo-propionic acid ethyl ester 
• 10601-80-6 ethyl 3,3-diethoxypropanoate 
• 471-25-0 Propiolic acid 
• 617-48-1 malic acid 
• 2067-86-9 8-formyl-7-hydroxycoumarin 

Downstream Products

• 109028-95-7 7-(2'-Oxocyclohexyloxy)-8-methylcoumarin 
• 1352006-35-9 dibenzyl 8-methyl-2-oxo-2H-chromen-7-yl phosphate 
• 93669-72-8 methyl-10 2H,8H benzo<1,2-b:5,4-b'>dipyranone-2 
• 15912-88-6 8-methylpsoralen 
• 14002-94-9 7-methoxy-8-methyl-2H-chromen-2-one 

Relevant articles and documents

Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins

Nine new 7-geranyloxycoumarin derivatives differently substituted at position 8 were semi-synthesised. Their topical anti-inflammatory activity was evaluated using the Croton oil ear test in mice as a model of acute inflammation. Auraptene (7-geranyloxycoumarin), its 8-methoxy (collinin, 1) and 8-acetoxy derivatives (5) (1μmol/cm2) provoked 50% oedema reduction, similarly to 0.25μmol/cm2 of the reference drug indomethacin, a nonsteroidal anti-inflammatory drug.

Photo-triggered fluorescent theranostic prodrugs as DNA alkylating agents for mechlorethamine release and spatiotemporal monitoring

We describe a new theranostic strategy for selective delivery and spatiotemporal monitoring of mechlorethamine, a DNA alkylating agent. A photo-responsive prodrug is designed and composed of a photolabile o-nitrophenylethyl group, a DNA alkylating mechlor

Synthesis of hydroxycoumarins and hydroxybenzo[f]- or [h]coumarins as lipid peroxidation inhibitors

Substituted hydroxycoumarins and 7- or 8-hydroxybenzo[f]coumarins were prepared by the treatment of phenols and naphthalenediols, respectively, with malic acid and H2SO4 under microwave irradiation. 7- or 8-Hydroxybenzo[f]coumarins and 6-hydroxybenzo[h]coumarin were synthesized by the reaction of naphthalenediols with ethylpropiolate in the presence of ZnCl2 in refluxing dioxane. The compounds were tested in vitro for their ability: (i) to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radical, (ii) to inhibit lipid peroxidation, (iii) to scavenge the superoxide anion, (iv) to inhibit the activity of soybean lipoxygenase and (v) to inhibit in vivo the carrageenin-induced rat paw edema. Most of them are potent superoxide anion scavengers and inhibit in vitro lipid peroxidation. The majority of the compounds did not show high lipoxygenase inhibitory activity. No differences were observed between biological responses of hydroxycoumarins and hydroxybenzocoumarins. Compound 3i was found to present a promising antioxidant profile.