27411-63-8Relevant articles and documents
S8-Catalyzed triple cleavage of bromodifluoro compounds for the assembly of N-containing heterocycles
Deng, Shuilin,Chen, Haohua,Ma, Xingxing,Zhou, Yao,Yang, Kai,Lan, Yu,Song, Qiuling
, p. 6828 - 6833 (2019/07/31)
An unprecedented S8-catalyzed selective triple-cleavage of bromodifluoroacetamides is disclosed for the first time. Valuable 2-amido substituted benzimidazoles, benzoxazoles and benzothiazoles were obtained in good to excellent yields in a casc
Azole-N-acetonitriles as carbonyl synthons: A one-pot preparation of heteroaryl amides from halides
Zhang, Zhongxing,Yin, Zhiwei,Kadow, John F.,Meanwell, Nicholas A.,Wang, Tao
, p. 2323 - 2326 (2007/10/03)
Azole-N-acetonitrile derivatives were utilized as synthons for an ambident carbonyl moiety via a strategy relying upon sequential base-mediated S NAr substitution of a 2-halo heterocycle, in situ oxidation, and amine displacement. This strategy allows prompt and efficient synthesis of N-containing heteroaryl amides directly from the corresponding halides via a one-pot process.