27514-07-4

Basic information

• Product Name: 7-Azabicyclo[2,2,1]heptane hydrochloride
• Synonyms: 7-AZABICYCLO[2,2,1]HEPTANE HCL;7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE
• CAS NO: 27514-07-4
• Molecular Formula: C₆H₁₁N*ClH
• Molecular Weight: 133.62
• Product Categories: pharmacetical
• Mol File: 27514-07-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 144.1 °C at 760 mmHg
• Flash Point: 30.6 °C
• Appearance: /
• Vapor Pressure: 5.17mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 7-Azabicyclo[2,2,1]heptane hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Azabicyclo[2,2,1]heptane hydrochloride(27514-07-4)
• EPA Substance Registry System: 7-Azabicyclo[2,2,1]heptane hydrochloride(27514-07-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 27514-07-4(Hazardous Substances Data)

Usage

General Description

7-Azabicyclo[2,2,1]heptane hydrochloride, also known as bicyclic guanidine, is a chemical compound with a bicyclic structure containing a nitrogen atom. It is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable intermediate in the production of various organic compounds. This chemical has been studied for its potential as a chiral catalyst in asymmetric synthesis and as a key component in the development of new drugs. Its hydrochloride form is commonly used to increase the solubility and stability of the compound in various applications.

InChI:InChI=1/C6H11N.ClH/c1-2-6-4-3-5(1)7-6;/h5-7H,1-4H2;1H

Upstream product

• 55258-02-1 7-methyl-7-aza-bicyclo[2.2.1]heptane 
• 27489-62-9 trans-4-aminocyclohexan-1-ol 
• 1272319-79-5 trans-4-aminocyclohexylmethanesulfonate trifluoroacetic acid salt 
• 177545-89-0 (1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl methanesulfonate 
• 111300-06-2 trans-tert-butyl 4-hydroxycyclohexylcarbamate 
• 27489-62-9 trans-4-hydroxycyclohexylamine 
• 279-40-3 7-aza-bicyclo[2.2.1]heptane 
• 343313-51-9 N-(trans-4-hydroxycyclohexyl)-4-methylbenzenesulfonamide 
• 50910-54-8 trans-4-aminocyclohexanol hydrochloride 
• 188624-92-2 7-[(4-methylphenyl)sulfonyl]-7-azabicyclo[2.2.1]heptane 
• 86852-11-1 diethoxyltriphenylphosphorane 

Downstream Products

• 1243606-68-9 2-amino-6-(7-azabicyclo[2.2.1]heptan-7-yl)-4-phenylpyridine-3,5-dicarbonitrile 
• 1221573-18-7 4-(7-azabicyclo[2.2.1] heptan-7-yl)-2-(trifluoromethyl)aniline 
• 1295570-08-9 4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)aniline hydrochloride 
• 1381886-72-1 1-(7-azabicyclo[2.2.1]heptanyl)-2-phenylethanone 
• 1381886-76-5 N-(2-phenylethyl)-7-azabicyclo[2.2.1]heptane 
• 1381886-79-8 N-(3-(3-fluorophenyl)propyl)-7-azabicyclo[2.2.1]heptane 
• 1381886-69-6 N-(3,4-dimethoxybenzyl)-7-azabicyclo[2.2.1]heptane 
• 1381886-67-4 N-(3-fluorobenzoyl)-7-azabicyclo[2.2.1]heptane 
• 1381886-68-5 N-(3-fluorobenzyl)-7-azabicyclo[2.2.1]heptane 
• 1381886-77-6 N-(2-(3-fluorophenyl)ethyl)-7-azabicyclo[2.2.1]heptane 
• 1381886-70-9 N-(cyclohexyl)methyl-7-azabicyclo[2.2.1]heptane 
• 1622401-46-0 benzyl(2-(7-azabicyclo[2.2.1]heptan-7-yl)-2-oxoethyl)carbamate 
• 643026-78-2 N-(p-chlorobenzoyl)-7-azabicyclo[2.2.1]heptane 
• 204691-94-1 N-(p-toluoyl)-7-azabicyclo[2.2.1]heptane 

Relevant articles and documents

Unexpected resistance to base-catalyzed hydrolysis of nitrogen pyramidal amides based on the 7-azabicyclic[2.2.1]heptane scaffold

Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported. Non-planar amides are generally sensitive to water or other n

7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands

A series of N-substituted 7-azabicyclo[2.2.1]heptanes (12-17 and 22-25) and similarly substituted pyrrolidines (32-36 and 41-44) were synthesized as sterically-reduced, achiral analogs of adamantane- and trishomocubane-derived σ ligands. In vitro competition binding assays against σ receptors revealed that arylalkyl N-substituents conferred selectivity for the σ2 subtype, while alicyclic or polycarbocyclic substituents imparted high affinity for both subtypes. The σ2 binding and subtype selectivities of N-arylalkyl-7-azanorbornanes was generally greater than the analogously-substituted pyrrolidines, indicating that steric bulk and conformational restriction around the nitrogen atom are likely important for subtype discrimination.

PROCESSES FOR PRODUCING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention relates to the process for producing modulators of cystic fibrosis transmembrane conductance regulator (CFTR).