1221573-18-7

Basic information

• Product Name: 4-(7-azabicyclo[2.2.1] heptan-7-yl)-2-(trifluoromethyl)aniline
• Synonyms: 4-(7-azabicyclo[2.2.1] heptan-7-yl)-2-(trifluoromethyl)aniline
• CAS NO: 1221573-18-7
• Molecular Weight: 256.271
• Mol File: 1221573-18-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 4-(7-azabicyclo[2.2.1] heptan-7-yl)-2-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(7-azabicyclo[2.2.1] heptan-7-yl)-2-(trifluoromethyl)aniline(1221573-18-7)
• EPA Substance Registry System: 4-(7-azabicyclo[2.2.1] heptan-7-yl)-2-(trifluoromethyl)aniline(1221573-18-7)

Safety Data

• Hazardous Substances Data: 1221573-18-7(Hazardous Substances Data)

Upstream product

• 393-09-9 4-fluoro-1-nitro-2-trifluoromethyl-benzene 
• 27489-62-9 trans-4-aminocyclohexan-1-ol 
• 1221573-19-8 7-[4-nitro-3-(trifluoromethyl) phenyl]-7-azabicyclo[2.2.1]heptane 
• 1272319-79-5 trans-4-aminocyclohexylmethanesulfonate trifluoroacetic acid salt 
• 27514-07-4 7-azabicyclo[2.2.1]heptane hydrochloride 
• 177545-89-0 (1r,4r)-4-((tert-butoxycarbonyl)amino)cyclohexyl methanesulfonate 
• 111300-06-2 trans-tert-butyl 4-hydroxycyclohexylcarbamate 
• 27489-62-9 trans-4-hydroxycyclohexylamine 

Downstream Products

• 1350805-17-2 C₁₈H₁₁F₆N₃O₂ 
• 1350805-16-1 C₂₄H₂₁F₆N₃O₃ 
• 1350805-15-0 C₂₄H₁₉F₆N₃O₄ 
• 1350805-14-9 C₂₄H₁₉F₆N₃O₄ 
• 1350805-13-8 C₂₄H₂₁F₆N₃O₄ 

Relevant articles and documents

PROCESSES FOR PRODUCING MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention relates to the process for producing modulators of cystic fibrosis transmembrane conductance regulator (CFTR).

SOLID FORMS OF N-(4-(7-AZABICYCLO[2.2.1]HEPTAN-7-YL)-2-TRIFLUOROMETHYL)PHENYL)-4-OXO-5-(TRIFLUOROMETHYL)-1,4-DIHYDROQUINOLINE-3-CARBOXAMIDE

The present invention relates to substantially crystalline and solid state forms of N-(4-(7-azabicyclo[2.2.1]heptan-7-yl)-2-(trifluoromethyl)phenyl)-4-oxo-5-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxamide (Form A-HCl, Form B, Form B-HCl, or any combination of these forms), pharmaceutical compositions thereof, and methods of treatment therewith.

MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator ( CFTR ), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.