2754-02-1

Basic information

• Product Name: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester
• CAS NO: 2754-02-1
• Molecular Formula: C20H30N2O5
• Molecular Weight: 378.469
• Mol File: 2754-02-1.mol
• Article Data: 40

Chemical Properties

• CAS DataBase Reference: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(2754-02-1)
• EPA Substance Registry System: L-Valine, N-[N-[(1,1-dimethylethoxy)carbonyl]-L-phenylalanyl]-, methyl ester(2754-02-1)

Safety Data

• Hazardous Substances Data: 2754-02-1(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 17498-50-9 L-valine hydrochloride 
• 4070-48-8 L-Valine methyl ester 
• 93605-47-1 (S)-methyl 2-(1H-imidazole-1-carboxamido)-3-methylbutanoate 
• 4070-48-8 L-valine methyl ester 
• 81000-39-7 (S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanethioic S-acid 
• 1446274-23-2 (S)-Se-((9H-fluorenyl)methyl) 2-((tert-butoxycarbonyl)amino)-3-phenylpropaneselenoate 
• 6306-52-1 L-valine methylester hydrochloride 
• 63-91-2 L-phenylalanine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 72-18-4 L-valine 
• 33857-75-9 N-tert-butoxycarbonyl-L-phenylalanine 2-pyridyl thiol ester 

Downstream Products

• 5196-43-0 tert-butyl ((S)-1-(((S)-1-hydrazinyl-3-methyl-1-oxobutan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate 
• 80870-38-8 (S)-methyl 2-((S)-2-amino-3-phenylpropanamido)-3-methylbutanoate 
• 58173-46-9 L-phenylalanyl-L-valine methyl ester hydrochloride 
• 47507-41-5 (S)-2-((S)-2-((tert-butoxycarbonyl)amino)-3-phenylpropanamido)-3-methylbutanoic acid 
• 938075-88-8 (CH₃)3COCONHCHCH₂C₆H₅CONH(CH)2(CH₃)2COF 
• 735200-29-0 L-Phe-L-Val-NH-NH-Z 
• 5196-44-1 tert.-Butyloxycarbonyl-L-Phe-L-Val-NH-NH-Z 
• 119621-70-4 C₂₆H₄₀N₄O₅ 

Relevant articles and documents

Phenysilane and Silicon Tetraacetate: Versatile Promotors for Amide Synthesis

Phenylsilane was reevaluated as a useful coupling reagent for amide synthesis. At room temperature, a wide range of amides and peptides were obtained in good to excellent yields (up to 99 %). For the first time, Weinreb amides synthesis mediated by a hydrosilane were also documented. Comparative experiments with various acetoxysilanes suggested the involvement of a phenyl-triacyloxysilane. From this mechanistic study, silicon tetraacetate was shown as an efficient amine acylating agent.

Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs

Curcumin (CUR) is a natural yellow pigment from turmeric with extensive bioactivities. However its relatively poor solubility limited its absorption and bioavailability. In this study, a novel series of CUR-peptide conjugates were designed and synthesized

Sequential One-Pot Synthesis of Dipeptides through the Transient Formation of CDI-N-Protected α-Aminoesters

The synthesis of dipeptides through a sequential one-pot procedure from commercially available protected amino acids is described. The transformation relies on the use of in situ generated transiently CDI-protected α-amino esters (CDI, e.g. N,N′-carbonyldiimidazole). In addition of being a highly atom-economical process, the couplings take place under very mild and neutral conditions without adding a base to the reaction medium. This protocol provides a concise and less costly route to dipeptide derivatives (12 examples, up to 87% yield) and is compatible with commonly used N-urethane protecting groups. Moreover, no epimerization was detected even when sensitive Boc-Cys(Bn)?OH was used. (Figure presented.).