2763-66-8

Basic information

• Product Name: N-CYCLOHEXYL-5-CHLOROVALERAMIDE
• Synonyms: N-5-CHLOROVALERYL CYCLOHEXYLAMINE;5-CHLORO-N-CYCLOHEXYLPENTANAMIDE
• CAS NO: 2763-66-8
• Molecular Formula: C₁₁H₂₁NO
• Molecular Weight: 217.74
• Mol File: 2763-66-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 332.6 °C at 760 mmHg
• Flash Point: 198 °C
• Appearance: /
• Density: 0.92 g/cm³
• Vapor Pressure: 0.000145mmHg at 25°C
• Refractive Index: 1.466
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: N-CYCLOHEXYL-5-CHLOROVALERAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-CYCLOHEXYL-5-CHLOROVALERAMIDE(2763-66-8)
• EPA Substance Registry System: N-CYCLOHEXYL-5-CHLOROVALERAMIDE(2763-66-8)

Safety Data

• Hazardous Substances Data: 2763-66-8(Hazardous Substances Data)

Usage

General Description

N-CYCLOHEXYL-5-CHLOROVALERAMIDE is a chemical compound with the molecular formula C11H19ClNO. It is a white to off-white crystalline powder that is used as an intermediate in the production of various pharmaceuticals and agrochemicals. N-CYCLOHEXYL-5-CHLOROVALERAMIDE is known for its ability to act as a benzodiazepine receptor ligand, which makes it useful in the development of medications for anxiety, insomnia, and other neurological disorders. It also has pesticidal properties, making it valuable in the development of crop protection products. N-CYCLOHEXYL-5-CHLOROVALERAMIDE is considered to be a versatile and important building block in the production of various chemical products.

InChI:InChI=1/C11H21NO/c1-2-3-9-11(13)12-10-7-5-4-6-8-10/h10H,2-9H2,1H3,(H,12,13)

Upstream product

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• 110-59-8 pentanonitrile 
• 110-82-7 cyclohexane 
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• 76-05-1 trifluoroacetic acid 
• 110-83-8 cyclohexene 
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Relevant articles and documents

Metal-free Photocatalytic Intermolecular anti-Markovnikov Hydroamination of Unactivated Alkenes

The development of photocatalytic intermolecular hydroamination reaction between N-aminated dihydropyridines and unactivated alkenes is reported. Metal-free co-catalysts, rhodamine 6G and thiophenol, in presence of visible light are used to initiate the process. The transformation shows a broad substrate scope, both alkenes and amidyl radical can act as coupling partners. The radical strategy provides excellent anti-Markovnikov selectivity and regioselectivity in diene substrates.

N-Acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides: Highly selective and efficient reagents for acylation of amines in water

A variety of N-acyl-N-(4-chlorophenyl)-4-nitrobenzenesulfonamides (1a-e) were synthesized in one pot from 4-chloroaniline under solvent-free conditions and have been developed as chemoselective N-acylation reagents. Selective protection of primary amines in the presence of secondary amines, acylation of aliphatic amines in the presence of aryl amines, and monofunctionalization of primary-secondary diamines as well as selective N-acylation of amino alcohols using these reagents are described. All of the acylation reactions were carried out in water as a green solvent. High stability and easy preparation of these acylating reagents are other advantages of this method.

THE DIRECT CONVERSION OF CARBOXYLIC ACIDS TO CARBOXAMIDES VIA REACTION WITH UNSOLVATED BIS(DIORGANOAMINO) MAGNESIUM REAGENTS

It has been found that unsolvated bis(diorganoamino) magnesium compounds react smoothly with carboxylic acids to give the corresponding carboxamides directly in good to excellent yields.