27688-56-8

Basic information

• Product Name: 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride
• Synonyms: 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride
• CAS NO: 27688-56-8
• Molecular Weight: 263.767
• Mol File: 27688-56-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride(27688-56-8)
• EPA Substance Registry System: 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride(27688-56-8)

Safety Data

• Hazardous Substances Data: 27688-56-8(Hazardous Substances Data)

Upstream product

• 81616-14-0 tert-butyl N-benzyl-N-methylcarbamate 
• 103-80-0 phenylacetyl chloride 

Downstream Products

• 23327-57-3 nefopam hydrochloride 

Relevant articles and documents

Preparation method for nefopam hydrochloride

The invention discloses a preparation method for nefopam hydrochloride. The preparation method is characterized by comprising the following preparation steps: (A) performing a reaction on raw materials including tert-butyl N-benzyl-N-methyl carbamate and benzoyl chloride to obtain an intermediate tert-butyl N-(2-(benzoyl)benzyl)-N-methyl carbamate; (B) performing reduction on the intermediate tert-butyl N-(2-(benzoyl)benzyl)-N-methyl carbamate by a reductant, and performing acidolysis to obtain an intermediate 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride; and (C) performinga reaction on the intermediate 1-((2-(methylamino)methyl)phenyl)-1-phenylmethanol hydrochloride and chloroacetyl chloride to form an amide through a one-pot method, performing cyclization, and performing reduction by a reductant to obtain the objective compound nefopam hydrochloride. According to the invention, the reaction steps are simple, and the preparation method is easy to implement.