27740-96-1

Basic information

• Product Name: 1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE
• Synonyms: (+/-) SALSOLINOL;1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE;(-)-(S)-Salsolinol;(S)-1,2,3,4-Tetrahydro-1-methyl-6,7-isoquinolinediol;(S)-Salsolinol;6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-methyl-, (S)-;(S)-1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methylisoquinoline
• CAS NO: 27740-96-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 195.22
• Mol File: 27740-96-1.mol
• Article Data: 10

Chemical Properties

• Melting Point: 257-260 °C
• Boiling Point: 362.6°C at 760 mmHg
• Flash Point: 175.4°C
• Appearance: /
• Density: 1.201g/cm³
• Vapor Pressure: 9.13E-06mmHg at 25°C
• Refractive Index: 1.588
• PKA: 9.15±0.40(Predicted)
• CAS DataBase Reference: 1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE(27740-96-1)
• EPA Substance Registry System: 1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE(27740-96-1)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-21/22
• Safety Statements: 36/37/39-26
• Hazardous Substances Data: 27740-96-1(Hazardous Substances Data)

Usage

Description

1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE is a chemical compound belonging to the dihydroisoquinoline class. It is a monohydrate form, containing one molecule of water, and is known for its potential pharmaceutical applications due to its antioxidant and neuroprotective properties.

Uses

Used in Pharmaceutical Industry:
1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE is used as a pharmaceutical agent for its potential antioxidant and neuroprotective properties. It is being studied for its potential use in the treatment of neurodegenerative diseases such as Parkinson's disease.
Used in Addiction and Substance Abuse Treatment:
1-METHYL-6,7-DIHYDROXY-3,4-DIHYDROISOQUINOLINE MONOHYDRATE is used as a therapeutic agent for its potential in treating addiction and substance abuse, offering a promising avenue for research and development in this field.

InChI:InChI=1/C10H13NO2/c1-6-8-5-10(13)9(12)4-7(8)2-3-11-6/h4-6,11-13H,2-3H2,1H3/t6-/m0/s1

Upstream product

• 51-61-6 dopamine 
• 75-07-0 acetaldehyde 
• 62-31-7 dopamine hydrochloride 
• 493-48-1 (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) 
• 63283-42-1 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride 

Downstream Products

• 114561-80-7 2-benzyl-6,7-bis-benzyloxy-1-methyl-1,2,3,4-tetrahydro-isoquinoline 
• 4593-97-9 N-Nor-1-methylcorypalline 
• 65644-76-0 (+/-)-N-Methylsalsoline 
• 19641-12-4 6-methoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinolin-7-ol 
• 89-31-6 rac-salsoline 
• 490-53-9 (+/-)-carnegine 
• 493-48-1 (6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline) 
• 1581289-16-8 C₁₈H₁₅F₆NO₄S 
• 1581289-14-6 C₁₆H₁₅N₃O₈S 
• 1581289-05-5 C₁₆H₁₅N₃O₈S 
• 51-61-6 dopamine 
• 53405-13-3 1,2,3,4-tetrahdyro-1-methylisopquinoline-7,8-diol 

Relevant articles and documents

Isosalsolinol formation: a secondary reaction in the Pictet Spengler condensation

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NEW USE OF ISOQUINOLINE DERIVATIVES FOR WOUND HEALING

The present invention is related to a method for wound healing comprising administering to a subject in need thereof a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound having the general Formula I, preferably salsolinol.

Monitoring on-chip pictet-spengler reactions by integrated analytical separation and label-free time-resolved fluorescence

High-throughput screening for optimal reaction conditions and the search for efficient catalysts is of eminent importance in the development of chemical processes and for expanding the spectrum of synthetic methodologies in chemistry. In this context we report a novel approach for a microfluidic chemical laboratory integrating organic synthesis, separation and time-resolved fluorescence detection on a single microchip. The feasibility of our integrated laboratory is demonstrated by monitoring the formation of tetrahydroisoquinoline derivatives by Pictet-Spengler condensation. After on-chip reaction the products and residual starting material were separated enantioselectively on the same chip. On-chip deep UV laser-induced fluorescence detection with time-correlated single photon counting was applied for compound assignment. The system was utilized to screen reaction conditions and various substrates for Pictet-Spengler reactions on-chip. Finally, the microlab was successfully applied to investigate enantioselective reactions using BINOL-based phosphoric acids as organocatalysts. Chip trick: An integrated chip-based approach for rapid monitoring of organic synthesis at the microscale level is presented. This is achieved by the integration of microfluidic channels for reaction and electrophoresis on a single device together with time-correlated single-photon counting for compound identification (see figure). Copyright