493-48-1Relevant articles and documents
Vancomycin-iridium (III) interaction: An unexplored route for enantioselective imine reduction
Facchetti, Giorgio,Pellegrino, Sara,Bucci, Raffaella,Nava, Donatella,Gandolfi, Raffaella,Christodoulou, Michael S.,Rimoldi, Isabella
supporting information, (2019/08/07)
The chiral structure of antibiotic vancomycin (Van) was exploited as an innovative coordination sphere for the preparation of an IrCp* based hybrid catalysts. We found that Van is able to coordinate iridium (Ir(III)) and the complexation was demonstrated by several analytical techniques such as MALDI-TOF, UV, Circular dichroism (CD), Raman IR, and NMR. The hybrid system so obtained was employed in the Asymmetric Transfer Hydrogenation (ATH) of cyclic imines allowing to obtain a valuable 61% e.e. (R) in the asymmetric reduction of quinaldine 2. The catalytic system exhibited a saturation kinetics with a calculated efficiency of Kcat/KM = 0.688 h?1mM?1
A One-Pot Process for the Enantioselective Synthesis of Amines via Reductive Amination under Transfer Hydrogenation Conditions
Williams, Glynn D.,Pike, Richard A.,Wade, Charles E.,Wills, Martin
, p. 4227 - 4230 (2007/10/03)
(Equation presented) Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.
METABOLISM OF SALSOLINOL BY TISSUE CULTURES OF SOME PAPAVERACEAE
Iwasa, K.,Kamigauchi, M.,Takao, N.
, p. 2973 - 2976 (2007/10/02)
(+/-)-Salsolinol, a substance possibly inducing Parkinsonism and alcoholism, was transformed into the 6- and 7-O-monomethylated salsolinols by various plant tissue cultures of Papaveraceae.Only 6-O-methylsalsolinol was further N-methylated to provide N-methylisosalsoline.Key Word Index - Corydalis ochotensis; C. opliocarpa; Macleaya cordata; Papaveraceae; tissue cultures; metabolism; isoquinoline alkaloid; salsolinol.