493-49-2

Basic information

• Product Name: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
• Synonyms: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;AKOS 233-63;3,4-Dihydro-6,7-dimethoxy-1(2H)-isoquinolinone;3,4-Dihydro-6,7-dimethoxyisoquinolin-1(2H)-one;6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-one;Corydaldine;6,7-DiMethoxy-3,4-dihydroisoquinolin-1(2H)-one
• CAS NO: 493-49-2
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.23
• Mol File: 493-49-2.mol
• Article Data: 34

Chemical Properties

• Melting Point: 175°
• Boiling Point: 346.25°C (rough estimate)
• Flash Point: 237.3°C
• Appearance: /
• Density: 1.1878 (rough estimate)
• Vapor Pressure: 5.83E-09mmHg at 25°C
• Refractive Index: 1.5100 (estimate)
• Storage Temp.: 2-8°C
• PKA: 14.23±0.20(Predicted)
• CAS DataBase Reference: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(493-49-2)
• EPA Substance Registry System: 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(493-49-2)

Safety Data

• Hazardous Substances Data: 493-49-2(Hazardous Substances Data)

Usage

General Description

6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-one is a chemical compound with the molecular formula C11H13NO3. It is a derivative of isoquinolinone and contains two methoxy groups on the 6 and 7 positions. 6,7-DIMETHOXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE has been studied for its potential pharmacological properties, particularly its effects on the central nervous system. It has been investigated as a potential drug candidate for various neurological disorders and as an analgesic. The precise mechanism of action and potential therapeutic applications of 6,7-Dimethoxy-3,4-dihydro-2H-isoquinolin-1-one are areas of ongoing research.

InChI:InChI=1/C11H13NO3/c1-14-9-5-7-3-4-12-11(13)8(7)6-10(9)15-2/h5-6H,3-4H2,1-2H3,(H,12,13)

Upstream product

• 853925-01-6 1-allyl-8,9-dimethoxy-1,2,3,5,6,10b-hexahydro-pyrrolo[2,1-a]isoquinoline 
• 15547-61-2 5,6-dimethoxy-indan-1-one oxime 
• 132589-67-4 2-(2,2-Dimethyl-propionyl)-6,7-dimethoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 67-56-1 methanol 
• 412337-64-5 6,7-dimethoxy-1-(2-nitro-benzyl)-3,4-dihydro-isoquinoline 
• 499140-42-0 6,7-dimethoxy-1-(3-methoxy-2-nitro-benzyl)-3,4-dihydro-isoquinoline 
• 56-23-5 tetrachloromethane 
• 17889-63-3 N-<2-(3,4-Dimethoxyphenyl)ethyl>carbamidsaeureethylester 
• 10025-87-3 trichlorophosphate 
• 98062-25-0 tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate 
• 35690-71-2 [2-(3,4-dimethoxy-phenyl)-ethyl]-carbamic acid methyl ester 
• 16101-63-6 6,7-dimethoxyisoquinoline-1(2H)-one 
• 55171-61-4 2-bromo-4,5-dimethoxybenzoyl chloride 
• 6286-46-0 2-bromo-4,5-dimethoxybenzoic acid 

Downstream Products

• 86425-88-9 5,6-dihydro-2,3,10-trimethoxy-8H-dibenzoquinolizin-8-one 
• 10211-78-6 8-oxypseudopalmatine 
• 66510-55-2 2-(3-chloropropyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisochinolinone 
• 131637-22-4 6,7-Dimethoxy-2-prop-2-ynyl-3,4-dihydro-2H-isoquinolin-1-one 
• 6514-05-2 6,7-dimethoxy-N-methyl-2H-3,4-dihydroisoquinolin-1-one 
• 24456-59-5 6,7-dimethoxy-3,4-dihydroisoquinoline-1(2H)-thione 
• 26665-00-9 5,6-dihydro-2,3,10,11-tetramethoxy-13-methyl-8H-dibenzoquinolizin-8-one 
• 243637-11-8 6,7-dimethoxy-1-oxo-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester 
• 116578-22-4 2-[N-Methyl-N-(4-(thien-2-yl)-butyl)-3-amino-propyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride 
• 103936-91-0 2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-6,7-dimethoxy-3,4-dihydroisoquinolin-1(2H)-one 
• 76201-90-6 6,7-dimethoxy-1-<(para-chloro)phenyl>-3,4-dihydroisoquinoline 
• 138505-03-0 13-ethyl-5,6-dihydro-2,3,10,11-tetramethoxy-8H-dibenzoquinolizin-8-one 
• 1745-07-9 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Solid-phase synthesis of isoquinolinones using Bischler-Napieralski cyclization

A traceless solid-phase synthetic approach to isoquinolinones is described here. This approach allows introducing both electron-donating as well as electron-withdrawing moieties on the benzene nuclei of isoquinolinones with high yields and purities. Isoquinolinone is a structural unit found in many natural products having various important biological activities. A traceless solid-phase synthetic approach has been developed to prepare isoquinolinone derivatives. This approach enables one to synthesize isoquinolinones having various moieties on benzene nuclei and also can produce derivatives with a proton on the amide nitrogen.

Easy Access to 2,4-Disubstituted Cyclopentenones by a Gold(III)-Catalyzed A3-Coupling/Cyclization Cascade

An efficient and convenient synthesis of 2,4-disubstituted cyclopentenones has been achieved through a Au(III)-catalyzed isomerization-A3-coupling/cyclization cascade. A possible mechanism involving an initial Au(III)-catalyzed isomerization, A3-type coupling, and cyclization via an enol intermediate is postulated.

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.