279684-32-1

Basic information

• Product Name: 2-(1'-Trimethylsilylhexyl)anisole
• Synonyms: 2-(1'-Trimethylsilylhexyl)anisole
• CAS NO: 279684-32-1
• Molecular Weight: 264.483
• Mol File: 279684-32-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(1'-Trimethylsilylhexyl)anisole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1'-Trimethylsilylhexyl)anisole(279684-32-1)
• EPA Substance Registry System: 2-(1'-Trimethylsilylhexyl)anisole(279684-32-1)

Safety Data

• Hazardous Substances Data: 279684-32-1(Hazardous Substances Data)

Upstream product

• 109-72-8 n-butyllithium 
• 75-77-4 chloro-trimethyl-silane 
• 612-15-7 o-methoxystyrene 
• 99522-22-2 o-(trimethylsilylmethyl)benzyl alcohol 

Downstream Products

• 99522-19-7 2-(1-Trimethylsilanyl-hexyl)-cyclohexanol 
• 99522-23-3 2-(1-Trimethylsilanyl-hexyl)-cyclohexanone 

Relevant articles and documents

Organolithium addition to styrene and styrene derivatives: Scope and limitations

Styrene and a range of aryl-substituted styrene derivatives are shown to undergo efficient carbolithiation-trapping reactions in diethyl ether at -78 to -25 °C. The reactivities of different types of organolithium reagents were found to be: tertiary, secondary > primary; ? alkenyl, methyl, phenyl. Electron donating groups (e.g. methoxy and dialkylamino) at the ortho- or para- positions of the benzene ring deactivate the double bond towards organolithium addition, but their reactions with butyllithium can be facilitated by using TMEDA as co-solvent. 2-Benzyloxystyrene and 2-allyloxystyrene undergo efficient carbolithiation at -78 °C, but at room temperature alkyl transfer occurs, generating the corresponding alkylated phenol. 2-Vinylnaphthalene also undergoes carbolithiation-carboxylation in reasonable yield.