279687-54-6

Basic information

• Product Name: 5-(4-Chlorophenyl)pyrrolidin-2-one
• Synonyms: 5-(4-Chlorophenyl)pyrrolidin-2-one;5-(4-chlorophenyl)-2-Pyrrolidinone
• CAS NO: 279687-54-6
• Molecular Formula: C10H10ClNO
• Molecular Weight: 195.6455
• Mol File: 279687-54-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-(4-Chlorophenyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chlorophenyl)pyrrolidin-2-one(279687-54-6)
• EPA Substance Registry System: 5-(4-Chlorophenyl)pyrrolidin-2-one(279687-54-6)

Safety Data

• Hazardous Substances Data: 279687-54-6(Hazardous Substances Data)

Usage

General Description

5-(4-Chlorophenyl)pyrrolidin-2-one, also known as 4-Cl-α-PVP or 4-chloro-α-pyrrolidinopentiophenone, is a synthetic cathinone and stimulant drug. It is a psychoactive substance that acts as a norepinephrine-dopamine reuptake inhibitor, leading to increased levels of dopamine and norepinephrine in the brain. 5-(4-Chlorophenyl)pyrrolidin-2-one is a derivative of α-PVP, and is known for its potential for abuse and addiction. It has been reported to produce effects such as increased energy, alertness, and euphoria, but can also lead to negative side effects and health risks, including cardiovascular problems, psychosis, and dependence. The use and sale of 5-(4-Chlorophenyl)pyrrolidin-2-one is often regulated and controlled in many countries due to its potential for misuse and harm.

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Relevant articles and documents

Highly Robust Iron Catalyst System for Intramolecular C(sp3)?H Amidation Leading to γ-Lactams

Disclosed here is the use of an iron catalyst system for an intramolecular C?H amidation toward γ-lactam synthesis from dioxazolone precursors. (Phthalocyanine)FeIIICl was found to catalyze this cyclization with extremely high turnover numbers of up to 47 000 under mild and aerobic conditions. On the basis of experimental and computational mechanistic studies, the reaction is suggested to proceed by a stepwise radical pathway involving fast hydrogen atom abstraction followed by radical rebound. A plausible origin for the high turnover numbers along with air-compatibility is also rationalized.

COMPOUND HAVING BET INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREFOR

The invention relates to the field of pharmaceutical chemistry. Specifically, the present invention relates to a series of BET (bromodomain and extra-terminal domain) inhibitors having a novel structure, particularly inhibitors targeting BRD4 (Bromodomain-containing protein 4), and a preparation method and use therefor. The structure thereof is shown in the following general formula (I). Said compounds or a stereoisomer, racemate, geometric isomer, tautomer, prodrug, hydrate, solvate, or crystal form thereof, or a pharmaceutically acceptable salt thereof, and the pharmaceutical compsosition thereof can be used for the treatment and/or prevention of related diseases mediated by bromodomain proteins.

Synthetic Utility of N-Benzoyloxyamides as an Alternative Precursor of Acylnitrenoids for γ-Lactam Formation

Described herein is the development of a new entry of acylnitrenoid precursors for γ-lactam synthesis via an intramolecular C-H amidation reaction. Upon Ir catalysis, N-benzoyloxyamides serve as efficient substrates to afford 5-membered amides. Mechanistic studies revealed that the generation of a putative Ir-carbonylnitrenoid via N-O bond cleavage is facilitated by the chelation of countercations. This protocol offers a convenient and step-economic route to γ-lactams starting from the corresponding carboxylic acids.