54654-08-9

Basic information

• Product Name: Benzenebutanoyl chloride, 4-chloro-
• Synonyms: Benzenebutanoyl chloride, 4-chloro-
• CAS NO: 54654-08-9
• Molecular Formula: C₁₀H₁₀Cl₂O
• Molecular Weight: 217.0918
• Mol File: 54654-08-9.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenebutanoyl chloride, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoyl chloride, 4-chloro-(54654-08-9)
• EPA Substance Registry System: Benzenebutanoyl chloride, 4-chloro-(54654-08-9)

Safety Data

• Hazardous Substances Data: 54654-08-9(Hazardous Substances Data)

Upstream product

• 4619-18-5 4-(4-chlorophenyl)butanoic acid 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 

Downstream Products

• 4521-18-0 4-(4-Chlorophenyl)butyric acid amide 
• 279687-54-6 5-(4-chlorophenyl)pyrrolidin-2-one 
• 1111702-16-9 N-(4,4-diethoxybutyl)-4-(4-chlorophenyl)-butyramide 
• 63998-62-9 4-(4-chlorophenyl)-butylamine 
• 79945-11-2 C₂₀H₂₇Cl₂N₃O₄S₂ 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 

Relevant articles and documents

Enantioselective Remote C(sp3)-H Cyanation via Dual Photoredox and Copper Catalysis

The remote C(sp3)-H cyanation of carboxamides has been described by merging photoredox and copper catalysis in a site-selective and enantiocontrolled manner. The protocol is the integration of photoinduced and nitrogen-centered radical-mediated intermolecular hydrogen atom transfer with chiral copper-complex-catalyzed radical cyanation. This strategy gives enantio-enriched cyanated amides in high yields.

A facile synthesis of pyrrolo-(di)-benzazocinones via an intramolecular N-acyliminium ion cyclisation

A facile, moderate to high yielding synthesis of hexahydro-(di)- benzazocinones is described via an intramolecular N-acyliminium ion cyclisation. The iminium ion intermediates are formed from the readily available 4,4-diethoxybutyl amides with an excess of triflic acid. For electron-withdrawing substituents, better yields were obtained from the pre-formed 2-hydroxypyrrolidine amides. From NMR studies, at ambient temperatures the pyrrolo-benzazocin-3-ones exist as a slowly equilibrating mixture of two conformations.

Bronchorelaxing compounds

A compound of the general formula (I) including its pharmaceutically acceptable acid addition salts wherein A is CHR9, wherein R9 is H, C1-C6 alkyl; n is 1-3; B is CHR10, wherein R10 is H, C1-C6 alkyl; m is 1 or 2; D is O or S or optionally NR16, wherein R16 is H, C1-C6 alkyl or C2-C6 acyl; E is CR11R12 or NR13, wherein R11 and R12 are, independent of each other, H or C1-C6 alkyl, R13 is H or C1-C6 alkyl; F is C1-C18 alkyl which may be mono- or di-unsaturated and/or substituted, is useful in treating and preventing pulmonary disease characterized by bronchoconstriction. Also disclosed are pharmaceutical compositions comprising the compound and methods for their manufacture.