27993-71-1

Basic information

• Product Name: Benzeneacetaldehyde, 2-chloro-a-oxo-
• CAS NO: 27993-71-1
• Molecular Formula: C8H5ClO2
• Molecular Weight: 168.579
• Mol File: 27993-71-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Benzeneacetaldehyde, 2-chloro-a-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetaldehyde, 2-chloro-a-oxo-(27993-71-1)
• EPA Substance Registry System: Benzeneacetaldehyde, 2-chloro-a-oxo-(27993-71-1)

Safety Data

• Hazardous Substances Data: 27993-71-1(Hazardous Substances Data)

Upstream product

• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 5000-66-8 2-chlorophenacyl bromide 

Downstream Products

• 72111-53-6 5-(2-chloro-phenyl)-pyrazine-2,3-dicarbonitrile 
• 203725-32-0 5-(2-Chlorophenyl)-1-phenyl-imidazolidine-2,4-dione 
• 32345-65-6 (DL)-o-chlorophenyl-1,2-ethanediol 
• 32345-65-6 (R)-(2-chlorophenyl)-1,2-ethanediol 
• 105702-28-1 3-(-o-chlorophenyl)pyrido<2,3-b>pyrazine 
• 118-91-2 ortho-chlorobenzoic acid 

Relevant articles and documents

Method for industrial production of tulobuterol

The invention discloses a method for industrial production of tulobuterol. The method comprises the following steps of 1, preparation of an intermediate II, wherein chloroacetophenone and an oxidant containing DMSO are added into a reaction kettle in sequence, a reaction is carried out for 1-1.5 hours under the condition of heat preservation, stirring is conducted until the reaction is completelyfinished, and through quenching, extraction, washing and concentration, the intermediate II is prepared; 2, preparation of a crude tulobuterol product, wherein the intermediate II, tert-butylamine, analcohol solvent and sodium borohydride are added into the reaction kettle in sequence and stirred, the reaction temperature is controlled, stirring is conducted until the reaction is completely finished, after concentration, extraction, washing and drying with a drying agent, filtration is conducted, and a filtrate is concentrated and recrystallized to obtain the crude tulobuterol product I; 3, refining of the tulobuterol, wherein the crude tulobuterol product I, an organic solvent and activated carbon for refinement of injection are recrystallized to obtain the refined tulobuterol. The industrial production method is green in reaction and simple in step and causes little pollution to the environment, the purity of the product is up to 99.95% or above, and the tulobuterol contains few impurities.

Oxidative C-C Bond Cleavage for the Synthesis of Aryl Carboxylic Acids from Aryl Alkyl Ketones

A metal-free and one-pot two-step synthesis of aryl carboxylic acids from aryl alkyl ketones has been achieved. The reactions were performed with iodine as the catalyst, DMSO and TBHP as the oxidants. Under the optimal reaction conditions, a number of aryl alkyl ketones could be converted into their corresponding aryl carboxylic acids in good to excellent yields (up to 94%).

Discovery of novel 2-(3-phenylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors

We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 2-phenylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GSK-3β inhibitors. SAR studies focused on the phenyl moiety revealed that a 4-fluoro-2-methoxy group afforded potent inhibitory activity toward GSK-3β. Based on docking studies, new hydrogen bonding between the nitrogen atom of the piperazine moiety and the oxygen atom of the main chain of Gln185 has been indicated, which may contribute to increased activity compared with that of the corresponding phenylmorpholine analogues. Effect of the stereochemistry of the phenylpiperazine moiety is also discussed.