280581-42-2

Basic information

• Product Name: 4-anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine
• Synonyms: 4-anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine
• CAS NO: 280581-42-2
• Molecular Weight: 357.209
• Mol File: 280581-42-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine(280581-42-2)
• EPA Substance Registry System: 4-anilino-5-bromo-2-(4-hydroxyanilino)pyrimidine(280581-42-2)

Safety Data

• Hazardous Substances Data: 280581-42-2(Hazardous Substances Data)

Upstream product

• 123-30-8 4-amino-phenol 
• 280581-50-2 5-bromo-2-chloro-N-phenylpyrimidin-4-amine 

Downstream Products

• 280580-84-9 4-Anilino-5-bromo-2-{4-[2-hydroxy-3-(4-methylpiperazin-1-yl)propoxy]anilino}pyrimidine 
• 280580-86-1 4-Anilino-5-bromo-2-{4-[3-(4-methylpiperazin-1-yl)propoxy]anilino}pyrimidine 
• 757175-72-7 4-Anilino-5-bromo-2-[4-(3-morpholinopropoxy)anilino]pyrimidine 
• 280581-41-1 4-Anilino-5-bromo-2-[4-(2,3-epoxypropoxy)anilino]pyrimidine 

Relevant articles and documents

2,4-Di(hetero-)arylamino(-oxy)-5-substituted pyrimidines as antineoplastic agents

Pyrimidine derivatives of formula (I) wherein Q1, Q2, G and R1 are as defined within; and pharmaceutically acceptable salts and in vivo hydrolysable esters thereof are described. Processes for their manufacture, pharmaceutical compositions and their use as cyclin-dependent serine/threonine kinase (CDK) and focal adhesion kinase (FAK) inhibitors are also described.

Cyclin-dependent kinase 4 inhibitors as a treatment for cancer. Part 2: Identification and optimisation of substituted 2,4-bis anilino pyrimidines

Through chemical modification and X-ray crystallography we identified the 2,4-bis anilino pyrimidines as potent inhibitors of CDK4. Herein, we describe the optimisation of this series.