28148-48-3

Basic information

• Product Name: 4-(2-CHLORO-ETHYL)-PYRIDINE
• Synonyms: 4-(2-CHLORO-ETHYL)-PYRIDINE;2-(pyridin-4-yl)ethyl chloride
• CAS NO: 28148-48-3
• Molecular Formula: C₇H₈ClN
• Molecular Weight: 141.6
• Mol File: 28148-48-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 231.646°C at 760 mmHg
• Flash Point: 116.156°C
• Appearance: /
• Density: 1.116g/cm³
• Vapor Pressure: 0.094mmHg at 25°C
• Refractive Index: 1.523
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-CHLORO-ETHYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-CHLORO-ETHYL)-PYRIDINE(28148-48-3)
• EPA Substance Registry System: 4-(2-CHLORO-ETHYL)-PYRIDINE(28148-48-3)

Safety Data

• Hazardous Substances Data: 28148-48-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H8ClN/c8-4-1-7-2-5-9-6-3-7/h2-3,5-6H,1,4H2

Upstream product

• 5344-27-4 4-(2-hydroxyethyl)pyridine 

Downstream Products

• 84200-06-6 3-(pyridin-4-yl)propanenitrile 
• 1144517-94-1 C₁₂H₁₉N₃ 
• 103505-44-8 1,1,1-trichloro-4-methoxy-3-[4]pyridyl-butan-2-ol 
• 6318-43-0 3-pyridin-4-yl-propionic acid 
• 100-43-6 4-vinylpyridine 
• 70289-28-0 4-(2-methoxyethyl)pyridine 

Relevant articles and documents

A study of the OH--induced β-elimination reactions of 2-(4-chloroethyl)pyridine, 2-(2-chloroethyl)pyridine, 1-methyl-2-(4-chloroethyl) pyridinium iodide and 1-methyl-2-(2-chloroethyl)pyridinium iodide in acetonitrile/water

Second-order rate constants have been determined for the title reactions in OH-/H2O and in OH-/ (CH3CN/H 2O) [30/70, 60/40, and 85/15 (v/v) mixtures]. A relatively small increase in reactivity is observed for the four substrates upon increasing the percentage of CH3CN in the solvent mixture. The methyl activating factors (kOH-NCH3/kOH-N) are also slightly affected by the solvent composition. On the other hand, the high acceleration of the reaction by methylation of the pyridine ring amounts to 104-106 according to an E1cb mechanism.

Optionally substituted pyrido[2,3-d]pyridine-2,4(1H,3H)-diones and pyrido[2,]pyrimidine-2(1H,3H)-ones

The present invention relates to optionally substituted pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones or optionally substituted pyrido[2,3-d]pyrimidine-2(1H,3H)-ones, i.e., compounds of Formula I: STR1 wherein: Y is --CH2 -- or --C(O)--; R1 is hydrogen or --(CH2)n --R7, wherein: R7 is aryl or heteroaryl, and n is 1 or 2, provided that when Y is --C(O)--, R7 is heteroaryl; and R2, R3, R4, R5 and R6 are hydrogen, or one is selected from lower alkyl, halo, carboxy, methoxycarbonyl, carbamoyl, methylcarbamoyl, di-methylcarbamoyl, methylcarbonyl, methylthio, methylsulfinyl, methylsulfonyl, hydroxymethyl, amino, trifluoromethyl, cyano or nitro; or R2, R3, R4 and R5 are independently selected from hydrogen, lower alkyl, nitro, chloro, fluoro, methoxycarbonyl or methylcarbonyl, provided at least one is hydrogen, and R6 is hydrogen; or a pharmaceutically acceptable ester, ether or salt thereof.