284462-74-4

Basic information

• Product Name: 2-Pyridinecarboxamide, 4-(4-amino-3-methylphenoxy)-N-methyl-
• Synonyms: 4-(2-(N-methylcarbamoyl)-pyridin-4-yloxy)-2-methylaniline;2-methyl-4-(2-(N-methylcarbamoyl)(4-pyridyloxy))aniline;4-(2-(N-methylcarbamoyl)-4-pyridyloxy)-2-methylaniline;4-(4-amino-3-methylphenoxy)-N-methylpicolinamide
• CAS NO: 284462-74-4
• Molecular Formula: C14H15N3O2
• Molecular Weight: 257.292
• Mol File: 284462-74-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 128.5 - 129.3 °C
• Boiling Point: 478.7±45.0 °C(Predicted)
• Density: 1.212±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Pyridinecarboxamide, 4-(4-amino-3-methylphenoxy)-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarboxamide, 4-(4-amino-3-methylphenoxy)-N-methyl-(284462-74-4)
• EPA Substance Registry System: 2-Pyridinecarboxamide, 4-(4-amino-3-methylphenoxy)-N-methyl-(284462-74-4)

Safety Data

• Hazardous Substances Data: 284462-74-4(Hazardous Substances Data)

Upstream product

• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 98-98-6 2-Picolinic acid 
• 2835-99-6 4-amino-3-methylphenol 
• 220000-87-3 4-chloro-N-methylpicolinamide 
• 284462-39-1 5-(4-aminophenoxy)isoindoline-1,3-dione 
• 327-78-6 4-chloro-3-(trifluoromethyl)phenyl isocyanate 

Relevant articles and documents

N,N'-bis-substituted aryl thiourea derivatives and synthetic method and application thereof

The invention discloses N,N'-bis-substituted aryl thiourea derivatives which are a series of compounds simultaneously containing various substituted aromatic ring structures and asymmetric substituted thiourea structures and are all novel structural compounds which are not reported in the literature. The biological activity test analysis of all the target compounds includes determination of DPPH antioxidant activity and antiviral activity. Results indicate that, in general, the designed and synthesized compounds are novel in structures and have the antioxidant activity and the antiviral activity revealed for the first time. In addition, the unknown biological activity is not fully elucidated, and thus the compounds are expected to provide a certain material basis for further research and development of new drugs.

6-O-SUBSTITUTED BENZOXAZOLE AND BENZOTHIAZOLE COMPOUNDS AND METHODS OF INHIBITING CSF-1R SIGNALING

Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors

This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.