28460-01-7 Usage
Description
DIETHYL METHYLTHIOMETHYLPHOSPHONATE is an organic compound with the chemical structure containing a phosphonate group, which is a key component in various chemical reactions and synthesis processes. It is known for its versatile reactivity and ability to form a wide range of products, making it a valuable compound in the field of organic chemistry.
Uses
Used in Pharmaceutical Industry:
DIETHYL METHYLTHIOMETHYLPHOSPHONATE is used as a reactant for the synthesis of various pharmaceutical compounds, including (+)-minfiensine. DIETHYL METHYLTHIOMETHYLPHOSPHONATE is synthesized via organocatalytic Diels-Alder/amine cyclization and 6-exo-dig radical cyclization, showcasing the versatility of DIETHYL METHYLTHIOMETHYLPHOSPHONATE in creating complex molecular structures.
Used in Chemical Synthesis:
In the field of chemical synthesis, DIETHYL METHYLTHIOMETHYLPHOSPHONATE is used as a reactant for the preparation of fused nitrogen, sulfur, and phosphorus-containing heterocycles. These heterocycles are essential building blocks in the development of new compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Antimicrobial Applications:
DIETHYL METHYLTHIOMETHYLPHOSPHONATE is also used as a reactant in the preparation of difurylpyridazine phosphonates, which exhibit antimicrobial activity. These compounds have potential applications in the development of new antimicrobial agents to combat drug-resistant bacteria and other pathogens.
Used in Stereochemistry:
In the field of stereochemistry, DIETHYL METHYLTHIOMETHYLPHOSPHONATE is used as a reactant for the preparation of phosphorus and sulfur stereoisomers of Et menthyl [(methylsulfinyl)methyl]phosphonate. These stereoisomers are crucial in understanding the relationship between the spatial arrangement of atoms in a molecule and its biological activity, which is essential for the development of more effective drugs and other chemical products.
Check Digit Verification of cas no
The CAS Registry Mumber 28460-01-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,4,6 and 0 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 28460-01:
(7*2)+(6*8)+(5*4)+(4*6)+(3*0)+(2*0)+(1*1)=107
107 % 10 = 7
So 28460-01-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H15O3PS/c1-4-8-10(7,6-11-3)9-5-2/h4-6H2,1-3H3
28460-01-7Relevant articles and documents
Reductions of phosphonodithioformates: Syntheses of α-phosphonyl thiols and hemidithioacetals
Makomo,Masson,Saquet
, p. 10277 - 10288 (1994)
The phosphonodithioformates appeared versatile precursors to the (mercaptomethyl)phosphonates and derivatives, through sodium borohydride reduction in acetonitrile heated under reflux. By contrast, when the reduction was performed at room temperature with
Free radical desulfenylation and deselenylation of α-sulfur and α-seleno substituted phosphonates with the n-Bu3SnH/AIBN reagents system.
Balczewski,Piotr
, p. 113 - 122 (2007/10/03)
Selestive desulfenylation and deselenylation of α-sulfur- and α-seleno-substituted phosphonates under free radical condition are described.Chemoselectivity and scope of title reaction were studied using phosphonates additionaly functionalized in the α-position alkyl, phenyl,ethoxy,chloro,carbonyl and sulfenyl groups.It was found the reduction of a halogen tolerates the presence of the sulfenyl group and the latter could be reduced in the presence of the sulfinyl and sulfonyl moieties.Moreover,one sulfenyl group was selectively removed from α-phosphoryl dithioacetals and the phenylsulphenyl group was reduced preferentially in the presence of the methylsulfenyl one. Key words:Desulfenylation,deselenylation,α-phosphoryl sulfides,α-phosphoryl selenides, tri-n-butyltinhydride,α,α-azaisobutyronitrile.
NEW SYNTHETIC METHOD OF O,S-THIOACETALS OF FORMYLPHOSPHONATES
Kim, Taek Hyeon,Oh, Dong Young
, p. 3479 - 3482 (2007/10/02)
The reaction of diethyl phosphonate with N-chlorosuccinimide (NCS) affords α-chloromethanephosphonate(5), which can be converted into a variety of O,S-thioacetals of formylphosphonates(2) by reaction with alcohols.
