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28535-81-1

28535-81-1

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28535-81-1 Usage

Description

Methyl 3-alpha,7-alpha-diacetoxy-12-oxo-5-beta-cholan-24-oate is a chemical compound that serves as an intermediate in the synthesis of 12β-Hydroxyisocholic Acid (H943480), which is a bile acid. Bile acids are essential for the digestion and absorption of dietary fats and fat-soluble vitamins in the body.

Uses

Used in Pharmaceutical Industry:
Methyl 3-alpha,7-alpha-diacetoxy-12-oxo-5-beta-cholan-24-oate is used as an intermediate in the synthesis of bile acids for pharmaceutical applications. The synthesis of 12β-Hydroxyisocholic Acid (H943480) is important in the development of medications that target bile acid-related conditions, such as cholesterol gallstones, liver diseases, and certain gastrointestinal disorders.
Used in Research and Development:
methyl 3-alpha,7-alpha-diacetoxy-12-oxo-5-beta-cholan-24-oate is also used in research and development for studying the structure, function, and potential therapeutic applications of bile acids. Understanding the properties and interactions of methyl 3-alpha,7-alpha-diacetoxy-12-oxo-5-beta-cholan-24-oate can contribute to the advancement of knowledge in the field of biochemistry and pharmacology.

Check Digit Verification of cas no

The CAS Registry Mumber 28535-81-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,5,3 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 28535-81:
(7*2)+(6*8)+(5*5)+(4*3)+(3*5)+(2*8)+(1*1)=131
131 % 10 = 1
So 28535-81-1 is a valid CAS Registry Number.

28535-81-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 3-α,7-α-diacetoxy-12-oxo-5-β-cholan-24-oate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:28535-81-1 SDS

28535-81-1Relevant articles and documents

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Plattner,Heusser

, p. 748,756 (1944)

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Engineering Regioselectivity of a P450 Monooxygenase Enables the Synthesis of Ursodeoxycholic Acid via 7β-Hydroxylation of Lithocholic Acid

Grobe, Sascha,Badenhorst, Christoffel P. S.,Bayer, Thomas,Hamnevik, Emil,Wu, Shuke,Grathwol, Christoph W.,Link, Andreas,Koban, Sven,Brundiek, Henrike,Gro?johann, Beatrice,Bornscheuer, Uwe T.

supporting information, p. 753 - 757 (2020/12/01)

We engineered the cytochrome P450 monooxygenase CYP107D1 (OleP) from Streptomyces antibioticus for the stereo- and regioselective 7β-hydroxylation of lithocholic acid (LCA) to yield ursodeoxycholic acid (UDCA). OleP was previously shown to hydroxylate testosterone at the 7β-position but LCA is exclusively hydroxylated at the 6β-position, forming murideoxycholic acid (MDCA). Structural and 3DM analysis, and molecular docking were used to identify amino acid residues F84, S240, and V291 as specificity-determining residues. Alanine scanning identified S240A as a UDCA-producing variant. A synthetic “small but smart” library based on these positions was screened using a colorimetric assay for UDCA. We identified a nearly perfectly regio- and stereoselective triple mutant (F84Q/S240A/V291G) that produces 10-fold higher levels of UDCA than the S240A variant. This biocatalyst opens up new possibilities for the environmentally friendly synthesis of UDCA from the biological waste product LCA.

Chenodeoxycholic acid derivatives, preparation method thereof and medical application thereof

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Paragraph 0045; 0046; 0047, (2018/06/26)

The invention relates to the field of medicinal chemistry, relates to chenodeoxycholic acid derivatives, a preparation method thereof and a medical application thereof, in particular to a kind of chenodeoxycholic acid derivatives with a general formula of (I), a preparation method thereof, a pharmaceutical composition comprising the compounds and medical application thereof, especially used as drugs for preventing or treating hyperlipidaemia, type II diabetes, atherosis and non-alcoholic steatohepatitis. The formula is shown in the description.

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