3749-87-9 Usage
Description
Methyl 3-alpha,7-alpha-diacetoxy-12-alpha-hydroxy-5-beta-cholan-24-oate is a chemical compound derived from bile acids. It is characterized by its unique molecular structure, which features two acetoxy groups at the 3-alpha and 7-alpha positions, a hydroxy group at the 12-alpha position, and a methyl group at the 24th position. Methyl 3-alpha,7-alpha-diacetoxy-12-alpha-hydroxy-5-beta-cholan-24-oate is known for its potential applications in various fields due to its structural properties.
Uses
Used in Pharmaceutical Industry:
Methyl 3-alpha,7-alpha-diacetoxy-12-alpha-hydroxy-5-beta-cholan-24-oate is used as an intermediate in the synthesis of 12β-Hydroxyisocholic Acid (H943480), a bile acid. This bile acid has potential therapeutic applications, particularly in the treatment of various liver and gallbladder disorders. Methyl 3-alpha,7-alpha-diacetoxy-12-alpha-hydroxy-5-beta-cholan-24-oate's role in the synthesis process is crucial for the development of medications targeting these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 3749-87-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,7,4 and 9 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3749-87:
(6*3)+(5*7)+(4*4)+(3*9)+(2*8)+(1*7)=119
119 % 10 = 9
So 3749-87-9 is a valid CAS Registry Number.
InChI:InChI=1/C29H46O7/c1-16(7-10-26(33)34-6)21-8-9-22-27-23(15-25(32)29(21,22)5)28(4)12-11-20(35-17(2)30)13-19(28)14-24(27)36-18(3)31/h16,19-25,27,32H,7-15H2,1-6H3
3749-87-9Relevant articles and documents
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Fieser et al.
, p. 4133 (1951)
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Chenodeoxycholic acid derivative or pharmaceutically acceptable salt thereof, and preparation method and applications thereof
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, (2020/03/12)
The invention discloses a chenodeoxycholic acid derivative with a structure as shown in general formula I or a medicinal salt thereof, and a preparation method and application of the chenodeoxycholicacid derivative. The chenodeoxycholic acid derivative can up-regulate the transcription levels of FXR mRNA and SHP mRNA, can obviously activate FXR, and can be used for preparing drugs for treating orpreventing hyperlipidemia, atherosclerosis, non-alcoholic steatohepatitis, type II diabetes mellitus and other diseases related to blood fat.
Chenodeoxycholic acid derivatives, preparation method thereof and medical application thereof
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, (2018/06/26)
The invention relates to the field of medicinal chemistry, relates to chenodeoxycholic acid derivatives, a preparation method thereof and a medical application thereof, in particular to a kind of chenodeoxycholic acid derivatives with a general formula of (I), a preparation method thereof, a pharmaceutical composition comprising the compounds and medical application thereof, especially used as drugs for preventing or treating hyperlipidaemia, type II diabetes, atherosis and non-alcoholic steatohepatitis. The formula is shown in the description.