2867-63-2Relevant articles and documents
Generation of Acyl Radical Equivalents by Cathodic Reduction of Acyl Tributylphosphonium Ions
Maeda, Hatsuo,Maki, Toshihide,Ohmori, Hidenobu
, p. 249 - 250 (1995)
The species generated by one-electron transfer to acyl tributylphosphonium ions has proved to be potent acyl radical equivalents by the results that unsubstituted and 6-phenyl- substituted 5-hexenoic acids were transformed into cyclopentanones by the electrolysis in the presence of Bu3P in an undivided cell, although the yields were not satisfactory due to the formation of 5-hexen-1-als via further one-electron reduction of the radicals before their cyclization.
Substituted cyclopropylamines from pyridinium ylide: Complexes of pentacarbonyl tungsten and enamines
Martin-Vaca, Bianca,Durand-Reville, Thomas,Audouin, Max,Rudler, Henri
, p. 1534 - 1538 (1998)
Enamines derived from cyclic ketones react very easily with a series of pyridinium ylide complexes of tungsten pentacarbonyl (CO)5W--C(R)(H) Py+ to give either at room temperature (for R = Ph) or at 40°C (for R = alkyl) substituted cyclopropylamines as mixtures of stereoisomers.
INHIBITORS OF NOROVIRUS AND CORONAVIRUS REPLICATION
-
, (2021/10/15)
Compounds of Formula (I) and methods of inhibiting the replication of viruses in a biological sample or patient, of reducing the amount of viruses in a biological sample or patient, and of treating a virus infection in a patient, comprising administering to said biological sample or patient an effective amount of a compound represented by Formula (I), a compound of Table A or B or a pharmaceutically acceptable salt thereof.
Umpolung Strategy for Arene C?H Etherification Leading to Functionalized Chromanes Enabled by I(III) N-Ligated Hypervalent Iodine Reagents
Mikhael, Myriam,Guo, Wentao,Tantillo, Dean J.,Wengryniuk, Sarah E.
supporting information, p. 4867 - 4875 (2021/09/14)
The direct formation of aryl C?O bonds via the intramolecular dehydrogenative coupling of a C?H bond and a pendant alcohol represents a powerful synthetic transformation. Herein, we report a method for intramolecular arene C?H etherification via an umpoled alcohol cyclization mediated by an I(III) N-HVI reagent. This approach provides access to functionalized chromane scaffolds from primary, secondary and tertiary alcohols via a cascade cyclization-iodonium salt formation, the latter providing a versatile functional handle for downstream derivatization. Computational studies support initial formation of an umpoled O-intermediate via I(III) ligand exchange, followed by competitive direct and spirocyclization/1,2-shift pathways. (Figure presented.).
Synthesis and structural characterization of facile ruthenium(II) hydrazone complexes: Efficient catalysts in α-alkylation of ketones with primary alcohols via hydrogen auto transfer
Kalaiarasi, Chinnasamy,Murugan, Kaliyappan,Vijayan, Paranthaman,Vijayapritha, Subbarayan,Viswanathamurthi, Periasamy
supporting information, (2020/08/06)
As a immersion for development of new complexes, new Ru(II) complexes (1–3) supported by benzothiazole hydrazine Schiff bases of the type [Ru(SAL-HBT)(CO)(AsPh3)2], [Ru(VAN-HBT)(CO)(AsPh3)2] and [Ru(NAP-HBT)(CO)Cl(AsPh3)2] [SAL-HBT = (salicyl((2-(benzothiazol-2yl)hydrazono)methylphenol)), VAN-HBT = 2-((2-(benzothiazol-2-yl)hydrazono)methyl)-6 methoxyphenol) and NAP-HBT = naphtyl-2-((2-(benzothiazol-2-yl)hydrazono)methyl phenol)] were synthesized. Their identities have been established by satisfactory elemental analyses, various spectroscopic techniques (IR, (1H, 13C) NMR) and also mass spectrometry. The ruthenium(II) ion exhibits a hexa coordination with distorted octahedral geometry. In complexes 1 and 2, the ligand coordinated as dianionic tridentate fashion by forming N^N donor five member and N^O donor six member chelate rings. However, in complex 3, the ligand coordinated as monoanionic bidentate fashion by forming N^N donor five-membered ring. The new ruthenium(II) carbonyl complexes were successfully applied as catalysts in α -alkylation of aliphatic and aromatic ketones with alcohols via borrowing hydrogen strategy. Various parameters such as base, solvent, temperature, time and catalyst loading on the catalytic activity were analyzed. From the results, the catalyst 1 was found to be the best catalyst for α-alkylation reaction to obtain excellent yield. The catalytic system has a broad substrate scope, which allows the synthesis of α-alkylated ketones in mild reaction conditions with low catalyst loading under air atmosphere.