287399-29-5 Usage
Description
4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid is an isotopically labeled analog of 4-Hydroxybenzoic Acid (S088120), which is a compound found in nature and is also used as the Impurity A of Acetylsalicylic Acid. This labeled version contains six carbon atoms replaced with the stable isotope carbon-13, making it a valuable tool for various analytical and research applications.
Uses
Used in Pharmaceutical Industry:
4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid is used as an impurity reference material for the identification and quantification of Impurity A in Acetylsalicylic Acid, which is commonly known as aspirin. The use of this isotopically labeled analog aids in the accurate determination of impurities, ensuring the quality and safety of the final drug product.
Used in Research and Development:
4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid serves as a valuable research tool in various scientific studies. It can be used for the investigation of metabolic pathways, enzyme activity, and other biochemical processes involving 4-Hydroxybenzoic Acid. The stable isotope labeling allows for the differentiation between the natural and labeled compounds, providing insights into the specific interactions and transformations occurring within the system.
Used in Analytical Chemistry:
In the field of analytical chemistry, 4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid can be employed as an internal standard for the quantification of 4-Hydroxybenzoic Acid and its derivatives in various samples. The use of an isotopically labeled analog as an internal standard improves the accuracy and precision of the measurements, making it a valuable tool for quality control and analytical research.
Used in Environmental Studies:
4-Hydroxybenzoic-1,2,3,4,5,6-13C6 Acid can also be utilized in environmental studies to trace the fate and transport of 4-Hydroxybenzoic Acid in ecosystems. The stable isotope labeling allows for the tracking of the compound's movement and transformation within the environment, providing valuable information on its ecological impact and potential risks to human health and the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 287399-29-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,7,3,9 and 9 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 287399-29:
(8*2)+(7*8)+(6*7)+(5*3)+(4*9)+(3*9)+(2*2)+(1*9)=205
205 % 10 = 5
So 287399-29-5 is a valid CAS Registry Number.
287399-29-5Relevant articles and documents
Synthesis method of p-hydroxybenzoic acid marked with stable isotope 13C or D
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Paragraph 0049; 0050; 0051, (2016/10/31)
The invention relates to a synthesis method of p-hydroxybenzoic acid marked with a stable isotope 13C or D. The method includes the following steps of firstly, adding the stable isotope into a reactor to mark phenol and promoter, sequentially adding an NaOH water solution and a main catalyst over stirring, continuing stirring, and adding carbon tetrachloride for heating reaction; secondly, conducting suction filtration, acidification, extraction, condensation and recrystallization to obtain a target product after reaction ends. Compared with the prior art, the method has the advantages that the method is simple in operation process, mild in reaction condition, free of high temperature and high pressure and suitable for synthesis of a stable isotope marked agent, the alignment selectivity of the obtained product reaches 100%, no subsequent chiral separation is needed, the purification process is simple and convenient, the chemical purity reaches 99% or above, and the isotopic abundance is 99 atom% or above.
