28785-04-8Relevant articles and documents
FUNGAL CELL WALL SYNTHESIS GENE
-
, (2008/06/13)
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
The Properties of Liquid Crystal Materials Incorporating the -CH2O- Inter-ring Linkage
Carr, N.,Gray, G. W.
, p. 27 - 44 (2007/10/02)
To establish more securely the influence of the -CH2O- inter-ring linkage upon the properties of mesogens of both high and low dielectric anisotropy, a range of ethers with the following general structure has been prepared and their properties examined. The thermal and electro-optic properties of the compounds are discussed, and comparisons made where possible with analogous materials incorporating the -CH2CH2- linkage.
KETONES-NEMATOGENS WITH MODERATE NEGATIVE DIELECTRIC ANISOTROPY AND HIGH CLEARING POINTS.
Osman,Huynh-Ba
, p. 141 - 152 (2007/10/02)
Anisotropic ketones whose rigid cores contain phenyl and cyclohexyl units were synthesized. The carbonyl group was incorporated either in the terminal substituents or in the link between the core units. The mesomorphic behavior of these ketones is described and correlated with their chemical structure. The 1-(4-alkanoylphenyl)-4-trans-alkylcyclohexanes as well as the 1-(4-alkanoylphenyl)-4-trans-alkanoylcyclohexanes show nematic phases. In contrast to laterally substituted compounds, these ketones have clearing points which are higher than those of the corresponding hydrocarbons. Another advantage of these nematogens is the ease of synthesis.