28785-04-8Relevant articles and documents
FUNGAL CELL WALL SYNTHESIS GENE
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, (2008/06/13)
A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed.Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.
Liquid crystal compounds
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, (2008/06/13)
A liquid crystal composition includes at least one compound of Formula (I) as follows: where A and B are substituted ring structures which include terminal alkyl groups, A being selected from: STR1 where R'1 is an alkyl group R1, an alkoxy group R1 O, an alkylcarbonyloxy group R1 CO.O or an alkoxycarbonyloxy group R1 OCO.O; STR2 where R1 is an alkyl group; or STR3 where R1 is an alkyl group; and B being selected from: STR4 where R'2 is an alkyl group R2, an alkoxy group OR2, an alkylcarbonyloxy group OCO.R2 or an alkoxycarbonyloxy group OCO.OR'2 ; and X is hydrogen or a cyano group or a methyl group or a halogen; STR5 where R2 is an alkyl group; or STR6 where R2 is an alkyl group; STR7 being a trans-1,4-disubstituted cyclohexane ring and STR8 a 1,4-disubstituted bicyclo(2,2,2)octane ring.
KETONES-NEMATOGENS WITH MODERATE NEGATIVE DIELECTRIC ANISOTROPY AND HIGH CLEARING POINTS.
Osman,Huynh-Ba
, p. 141 - 152 (2007/10/02)
Anisotropic ketones whose rigid cores contain phenyl and cyclohexyl units were synthesized. The carbonyl group was incorporated either in the terminal substituents or in the link between the core units. The mesomorphic behavior of these ketones is described and correlated with their chemical structure. The 1-(4-alkanoylphenyl)-4-trans-alkylcyclohexanes as well as the 1-(4-alkanoylphenyl)-4-trans-alkanoylcyclohexanes show nematic phases. In contrast to laterally substituted compounds, these ketones have clearing points which are higher than those of the corresponding hydrocarbons. Another advantage of these nematogens is the ease of synthesis.