288148-34-5

Basic information

• Product Name: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)
• Synonyms: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI);1H-pyrazole-4-sulfonyl chloride, 1-methyl-;1-methyl-1H-pyrazole-4-sulfonyl chloride(SALTDATA: FREE);1-Methyl-1H-pyrazole-4-sulphonyl chloride;4-(Chlorosulphonyl)-1-methyl-1H-pyrazole;1-methyl-4-pyrazolesulfonyl chloride;1-methylpyrazole-4-sulfonyl chloride;EOS-61290
• CAS NO: 288148-34-5
• Molecular Formula: C₄H₅ClN₂O₂S
• Molecular Weight: 180.6127
• Product Categories: SULFONYLHALIDE
• Mol File: 288148-34-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 364.206°C at 760 mmHg
• Flash Point: 174.066°C
• Appearance: /
• Density: 1.706g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: -3.33±0.10(Predicted)
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)(288148-34-5)
• EPA Substance Registry System: 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI)(288148-34-5)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• RIDADR: UN3265
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 288148-34-5(Hazardous Substances Data)

Usage

Description

1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) is an organic chemical compound with the molecular formula C4H4N2O2SCl. It is a derivative of 1-methyl-1H-pyrazole, featuring a sulfonyl chloride group attached to the 4-position of the pyrazole ring. 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) is known for its reactivity and is commonly used in the synthesis of various pharmaceuticals and organic compounds.

Uses

Used in Pharmaceutical Industry:
1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) is used as a reagent for the preparation of benzoindazoles, which are glucocorticoid receptor modulators. These benzoindazoles have potential applications in the treatment of various inflammatory and immune-mediated disorders, as they can modulate the activity of the glucocorticoid receptor, a key regulator of inflammation and immune response.
In the synthesis of benzoindazoles, 1H-Pyrazole-4-sulfonylchloride,1-methyl-(9CI) serves as a key intermediate, providing a sulfonyl chloride group that can be further reacted with other organic compounds to form the desired benzoindazole structure. This reagent plays a crucial role in the development of new therapeutic agents with improved efficacy and safety profiles for the treatment of various diseases.

InChI:InChI=1/C3H3ClN2O2S/c4-9(7,8)3-1-5-6-2-3/h1-2H,(H,5,6)

Upstream product

• 930-36-9 1-methyl-1H-pyrazole 
• 39806-90-1 4-iodo-1-methyl-1H-pyrazole 

Downstream Products

• 1380229-22-0 N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-1-methyl-1H-pyrazole-4-sulfonamide 

Relevant articles and documents

SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula (I) and their use in the treatment of migraine: where A is C(H)= or N=; m is 0, 1 or 2; R1 is optionally substituted phenyl, optionally substituted pyrazol-4-yl; optionally substituted imidazolyl, optionally substituted pyridyl, or thienyl; R2 is hydrogen or methyl; and R3 and R4 are as defined herein.

STEROID SPARING AGENTS AND METHODS OF USING SAME

This invention relates generally to the use of a steroid sparing agent for the preparation of a medicament for the treatment of inflammatory bowel diseases (IBD), asthma, multiple sclerosis (MS), rheumatoid arthritis (RA), graft versus host disease (GVHD), host versus graft disease, and various spondyloarthropathies, comprising administering a steroid sparing immunoglobulin or small molecule composition to a patient in need thereof. The invention also relates generally to combination therapies for the treatment of these conditions.