288399-19-9

Basic information

• Product Name: Quinoline, 4-(chloromethyl)-2-methyl- (9CI)
• Synonyms: Quinoline, 4-(chloromethyl)-2-methyl- (9CI);4-Chloromethyl-2-methylquinoline;4-(Chloromethyl)-2-methyl-1-azanaphthalene;Quinoline, 4-(chloromethyl)-2-methyl
• CAS NO: 288399-19-9
• Molecular Formula: C₁₁H₁₀ClN
• Molecular Weight: 191.6568
• Product Categories: HALOMETYL
• Mol File: 288399-19-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 316.779°C at 760 mmHg
• Flash Point: 174.734°C
• Appearance: /
• Density: 1.192g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.45±0.50(Predicted)
• CAS DataBase Reference: Quinoline, 4-(chloromethyl)-2-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 4-(chloromethyl)-2-methyl- (9CI)(288399-19-9)
• EPA Substance Registry System: Quinoline, 4-(chloromethyl)-2-methyl- (9CI)(288399-19-9)

Safety Data

• Hazardous Substances Data: 288399-19-9(Hazardous Substances Data)

Usage

Description

Quinoline, 4-(chloromethyl)-2-methyl(9CI) is an organic compound belonging to the quinoline family, characterized by its fused six-membered and five-membered nitrogen-containing rings. It features a chloromethyl group at the 4-position and a methyl group at the 2-position, which can be utilized in various chemical reactions and applications.

Uses

Used in Pharmaceutical Industry:
Quinoline, 4-(chloromethyl)-2-methyl(9CI) is used as a reagent for the synthesis of Tumor Necrosis Factor-α converting enzyme (TACE) inhibitors. These inhibitors play a crucial role in the development of medications targeting various inflammatory and autoimmune diseases by modulating the activity of TACE, an enzyme involved in the release of pro-inflammatory cytokines.

InChI:InChI=1/C11H10ClN/c1-8-6-9(7-12)10-4-2-3-5-11(10)13-8/h2-6H,7H2,1H3

Upstream product

• 4939-28-0 4-(hydroxymethyl)-2-methylquinoline 

Downstream Products

• 556052-12-1 2-methyl-2-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-malonic acid dimethyl ester 
• 556051-85-5 2-methyl-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzyl]-malonic acid dimethyl ester 
• 556052-02-9 2-Methyl-2-{(E)-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-allyl}-malonic acid dimethyl ester 
• 556052-06-3 2-methyl-2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-malonic acid dimethyl ester 
• 676606-75-0 4-[(2-methyl-4-quinolinyl)methoxy]benzyl alcohol 
• 637362-71-1 C₂₉H₃₄N₂O₅ 
• 301162-82-3 [4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-acetic acid methyl ester 
• 648414-76-0 (S)-4-Benzyl-3-(2-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-propionyl)-oxazolidin-2-one 
• 300856-37-5 (S)-tert-Butoxycarbonylamino-{(R)-1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-acetic acid methyl ester 
• 648418-38-6 N-tert-butoxy-N-(1-{1-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-3-yl}-ethyl)-formamide 
• 607710-13-4 4-[(2-methyl-4-quinolyl)methoxy]benzenesulfonyl chloride 
• 477585-26-5 sodium 4-(2-methylquinolin-4-ylmethoxy)benzenesulfonate 
• 1260170-91-9 methyl (S)-2-(4-methanesulfonylpiperazin-1-yl)-3-[4-(2-methylquinolin-4-ylmethoxy)benzenesulfonylamino]propanoate 
• 1270808-99-5 methyl (S)-3-[4-(2-methylquinolin-4-ylmethoxy)-benzoylamino]-2-piperidin-1-ylpropanoate 

Relevant articles and documents

SULPHONAMIDE DERIVATIVES AND THEIR USE AS TACE INHIBITORS

Sulphonamide derivatives that are useful in the inhibition of metalloproteinases and in particular in the inhibition of TNF-α Converting Enzyme (TACE).