556052-06-3

Basic information

• Product Name: 2-methyl-2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-malonic acid dimethyl ester
• CAS NO: 556052-06-3
• Molecular Weight: 435.52
• Mol File: 556052-06-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-malonic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-malonic acid dimethyl ester(556052-06-3)
• EPA Substance Registry System: 2-methyl-2-{3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-propyl}-malonic acid dimethyl ester(556052-06-3)

Safety Data

• Hazardous Substances Data: 556052-06-3(Hazardous Substances Data)

Upstream product

• 556052-05-2 2-[3-(4-hydroxy-phenyl)-propyl]-2-methyl-malonic acid dimethyl ester 
• 288399-19-9 4-(chloromethyl)-2-methylquinoline 
• 141222-05-1 3-<4-<<(1',1'-dimethylethyl)dimethylsilyl>oxy>phenyl>prop-2-enyl bromide 
• 609-02-9 methyl-malonic acid dimethylester 
• 556052-04-1 2-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propyl}-2-methyl-malonic acid dimethyl ester 
• 556052-00-7 2-{3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-allyl}-2-methyl-malonic acid dimethyl ester 

Relevant articles and documents

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

Using a pyrimidine-2,4,6-trione motif as a zinc-binding group, a series of selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) was discovered. Optimization of initial lead 1 resulted in a potent inhibitor (51), with an IC50