292606-35-0

Basic information

• Product Name: 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE
• Synonyms: tert-Butyl N-(3-amino-2,2-dimethylpropyl)carbamate;N-Boc-2,2-dimethyl-1,3-diaminopropane;CarbaMic acid, N-(3-aMino-2,2-diMethylpropyl)-, 1,1-diMethylethyl ester;N-Boc-2,2-dimethyl-1,3-propanediamine tert-Butyl (3-Amino-2,2-dimethylpropyl)carbamate (3-Amino-2,2-dimethylpropyl)carbamic Acid tert-Butyl Ester N-Boc-2,2-dimethyl-1,3-diaminopropane;N-(tert-Butoxycarbonyl)-2,2-dimethyl-1,3-propanediamine;1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE;BOC-1-AMINO-2,2-DIMETHYL-1,3-PROPYLDIAMINE;Carbamic acid, (3-amino-2,2-dimethylpropyl)-, 1,1-dimethylethyl ester (9CI)
• CAS NO: 292606-35-0
• Molecular Formula: C₁₀H₂₂N₂O₂
• Molecular Weight: 202.29
• Product Categories: N-BOC;pharmacetical;Monoprotected Diaminoalkanes;N-Boc-diaminoalkanes
• Mol File: 292606-35-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 74 °C
• Boiling Point: 293.768 °C at 760 mmHg
• Flash Point: 131.466 °C
• Appearance: /
• Density: 0.965 g/cm³
• Vapor Pressure: 0.00169mmHg at 25°C
• Refractive Index: 1.458
• PKA: 12.86±0.46(Predicted)
• CAS DataBase Reference: 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE(292606-35-0)
• EPA Substance Registry System: 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE(292606-35-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 292606-35-0(Hazardous Substances Data)

Usage

General Description

1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE is a chemical compound that belongs to the category of organic compounds known as boc-protected amines. It is a complex amine used in chemical synthesis and pharmaceutical research. 1-BOC-AMINO-2,2-DIMETHYL-1,3-PROPANEDIAMINE is also known for its use in the creation of a variety of synthetic products, including polymers and resins, and elements in drug discovery and development. It's characterized by a structure that contains a trivalent N-BOC protected diamine functional group, which provides the capability to engage in a variety of chemical reactions. Its molecular formula is C8H18N2O2.

InChI:InChI=1/C10H22N2O2/c1-9(2,3)14-8(13)12-7-10(4,5)6-11/h6-7,11H2,1-5H3,(H,12,13)

Upstream product

• 1384724-40-6 C₁₂H₂₁F₃N₂O₃ 
• 1321622-57-4 N-(3-amino-2,2-dimethylpropyl)-2,2,2-trifluoroacetamide 
• 7328-91-8 2,2-Dimethyl-1,3-diaminopropane 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 925923-08-6 tert-butyl (3-{[(3-{3-cyano-6-[4-fluoro-2-(methoxymethoxy)phenyl]-2-[(furan-2-ylcarbonyl)amino]pyridin-4-yl}phenyl)carbonyl]amino}-2,2-dimethylpropyl)carbamate 
• 1384724-42-8 tert-butyl (2,2-dimethyl-3-(2-nitrophenylsulfonamido)propyl)carbamate 
• 1604813-29-7 tert-butyl (3-(4-((4-((4-(3-bromopropoxy)-3-chlorobenzyl)amino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate 
• 1604812-99-8 C₃₆H₃₆F₃N₉O₅ 
• 1604812-98-7 C₃₅H₃₅ClF₄N₈O₅ 
• 1604813-22-0 tert-butyl 3-(4-(4-(4-(2-(chloromethyl)allyloxy)benzylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-ylamino)benzamido)-2,2-dimethylpropylcarbamate 
• 1449410-37-0 tert-butyl 3-(4-{[4-(1-(4-chlorophenyl)cyclopropylamino)-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]amino}benzamido)-2,2-dimethylpropylcarbamate 
• 1430195-72-4 tert-butyl (3-(4-((4-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-2-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate 
• 1430195-65-5 tert-butyl (3-(4-((2-((4-(3-bromopropoxy)benzyl)amino)-6-(2,2,2-trifluoroethoxy)pyrimidin-4-yl)amino)benzamido)-2,2-dimethylpropyl)carbamate 

Relevant articles and documents

3-OXO-1,4-DIAZEPINYLE COMPOUNDS AS NRF2 ACTIVATORS

The present invention relates to bisaryl lactam compounds, methods of making them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the compounds of this invention include a compound of Formula (I):

Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug

The embodiments provide Compound KC-8, N-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, Compound KC-8, that provides controlled release of oxycodone. Such compositions can optionally provide a trypsin inhibitor that interacts with the enzyme that mediates the controlled release of oxycodone from the prodrug so as to attenuate enzymatic cleavage of the prodrug.

AMINE COMPOUNDS AND USE THEREOF

It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(=O) or NR11; and D is a group represented by the following general formula (4) or (6).-Q-Y-BIn the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.