29270-33-5

Basic information

• Product Name: ALPHA-BROMO-4-FLUOROPHENYLACETIC ACID 9
• Synonyms: ALPHA-BROMO-4-FLUOROPHENYLACETIC ACID 9;α-bromo-4-fluorophenylacetic acid;ALPHA-BROMO-(4-FLUOROPHENYL) ACETIC ACID, METHYL ESTER
• CAS NO: 29270-33-5
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.035
• Product Categories: C8;Carbonyl Compounds;Carboxylic Acids
• Mol File: 29270-33-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 96-100 °C
• Boiling Point: 288.2°C at 760 mmHg
• Flash Point: 128.1°C
• Appearance: White to brown/Powder
• Density: 1.725g/cm³
• Vapor Pressure: 0.0011mmHg at 25°C
• Refractive Index: 1.582
• PKA: 2.37±0.10(Predicted)
• CAS DataBase Reference: ALPHA-BROMO-4-FLUOROPHENYLACETIC ACID 9(CAS DataBase Reference)
• NIST Chemistry Reference: ALPHA-BROMO-4-FLUOROPHENYLACETIC ACID 9(29270-33-5)
• EPA Substance Registry System: ALPHA-BROMO-4-FLUOROPHENYLACETIC ACID 9(29270-33-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 29270-33-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6BrFO2/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7H,(H,11,12)

Upstream product

• 81228-09-3 2,4-difluorophenylacetic acid 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 451-82-1 (2-fluorophenyl)acetic acid 
• 1878-66-6 4-chlorophenylacetic Acid 
• 351-35-9 3-(trifluoromethyl)phenylacetic acid 
• 4315-07-5 4-(trifluoromethoxy)phenylacetic acid 
• 331-25-9 (3-fluorophenyl)acetic acid 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 581-96-4 2-naphthylacetic acid 
• 104-03-0 4-nitrobenzeneacetic acid 
• 209991-64-0 2-(2-fluoro-4-(trifluoromethyl)phenyl)acetic acid 
• 203302-97-0 2-(3-(trifluoromethoxy)phenyl)acetic acid 
• 243666-12-8 2-(2,3,4-trifluorophenyl)acetic acid 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 

Downstream Products

• 151295-13-5 S-(2-chloro-3-fluoro-6-nitrophenyl)-α-mercapto-4-fluorobenzeneacetic acid 
• 1352299-43-4 3-tert-butyl-5-(4-fluorophenyl)-1-(((4R,6R)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)imidazolidine-2,4-dione 
• 1118749-88-4 (4-[3-benzyl-4-(4-fluorophenyl)-2,5-dioxo-imidazolidin-1-yl]-phenyl)-carbamic acid benzyl ester 
• 1118749-89-5 5-(4-fluorophenyl)-1,3-bis-(4-methoxyphenyl)-imidazolidine-2,4-dione 
• 689254-66-8 methyl(R)-amino-(4-fluorophenyl)-acetate 
• 1118749-87-3 1-benzyl-3-tert-butyl-5-(4-fluorophenyl)-imidazolidine-2,4-dione 
• 1241914-91-9 (R,S)-2-((4-fluorophenyl)(methoxy)methyl)quinazolin-4-yl 2,4,6-triisopropylbenzenesulfonate 
• 1241914-90-8 (R,S)-2-((4-fluorophenyl)(methoxy)methyl)quinazolin-4-ol 
• 1241914-88-4 (R,S)-2-((4-fluorophenyl)(methoxy)methyl)-N-(5-methyl-1H-pyrazol-3-yl)quinazolin-4-amine 
• 1241914-89-5 (R,S)-2-(2-bromo-2-(4-fluorophenyl)acetamido)benzamide 
• 1241915-11-6 2-(2-bromo-2-(4-fluorophenyl)acetamido)-4-fluorobenzamide 

Relevant articles and documents

Synthesis of di-, tri-, and tetrasubstituted pyridines from (phenylthio)carboxylic acids and 2-[aryl(tosylimino)methyl]acrylates

An isothiourea-catalyzed Michael addition-lactamization followed by the sulfide oxidation-elimination/N- to O-sulfonyl transfer sequence for the formation of 2,3,5- and 2,3-substituted pyridine 6-tosylates from (phenylthio)acetic acids and α,β-unsaturated

Anti-viral compounds

The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1is hydrogen, halo, CN, C1-C4alkyl, —C≡CH, CO(C1-C4alkyl), CO2(C1-C4alkyl), or CONR2R3; R2and R3are independently hydrogen or C1-C4alkyl; A′ is hydrogen, halo, C1-C6alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4is C1-C6alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4alkyl, or CO2(C1-C4alkyl), C1-C4alkoxy; or a pharmaceutically acceptable salt thereof.

Synthesis and Antineoplastic Activity of Bisoxy>methyl>-Substituted 3-Pyrrolines as Prodrugs of Tumor Inhibitory Pyrrole Bis(carbamates)

A series of bispyrrolines 2-4 were synthesized from either the appropriate α-silylated iminium salt, or an aziridine, or a 2H-azirine in a sequence involving 1,3-dipolar cycloaddition reactions.The antineoplastic activities of the pyrrolines were compared to the corresponding pyrroles.The C-2 gem-dimethyl-substituted pyrroline, 4, which cannot be converted to the pyrrole in vivo, was inactive.The activity of the 2-phenyl-substituted pyrrolines 3 was markedly dependent on the nature of the phenyl substituent, although the correspondingphenylpyrroles all showed comparable activity.The differences in the activities of the pyrrolines 3 may be due to the rate of metabolic conversion of the pyrroline to the pyrrole.Electron-withdrawing substituents on the phenyl ring appear to retard this process.